Remodeling of skeletal muscle microvasculature in sickle cell trait and alpha-thalassemia

American Journal of Physiology. Heart and Circulatory Physiology
Lucile VincentLaurent Messonnier

Abstract

The influence of sickle cell trait and/or alpha-thalassemia on skeletal muscle microvascular network characteristics was assessed and compared with control subjects [hemoglobin (Hb) AA] in 30 Cameroonian residents [10 HbAA, 5 HbAA alpha-thalassemia (alpha-t), 6 HbAS, and 9 HbASalpha-t] matched for maximal work capacity and daily energy expenditure. Subjects performed an incremental exercise to exhaustion and underwent a muscle biopsy. Muscle fiber type and surface area were not different among groups. However, sickle cell trait (SCT) was associated with lower capillary density (P < 0.05), lower capillary tortuosity (P < 0.001), and enlarged microvessels (P < 0.01). SCT carriers had reduced counts of microvessels <5-microm diameter, but a higher percentage of broader microvessels, i.e., diameter >10 microm (P < 0.05). alpha-Thalassemia seemed to be characterized by a higher capillary tortuosity and unchanged capillary density and diameter. Thus, while SCT is a priori clinically benign, we demonstrate for the first time that significant remodeling of the microvasculature occurs in SCT carriers. These modifications may possibly reflect protective adaptations against hemorheological and microcirculatory dysfunction induced by the p...Continue Reading

References

Sep 1, 1977·The Journal of Physiology·P Andersen, J Henriksson
Jan 1, 1979·British Journal of Haematology·G R SerjeantB E Serjeant
Feb 28, 1979·Cell and Tissue Research·H J Appell, F Hammersen
Jan 1, 1975·International Urology and Nephrology·S O HietalaO Hassler
Jul 1, 1975·British Journal of Haematology·M H Steinberg
Apr 1, 1992·Physiological Reviews·O HudlickaS Egginton
Jan 1, 1987·Microvascular Research·O Mathieu-Costello
Sep 24, 1987·The New England Journal of Medicine·J A KarkC J Ruehle
Jan 1, 1987·The American Journal of Physiology·S M Sullivan, R N Pittman
Dec 1, 1986·Acta Neurologica Scandinavica·E RanklevH Kalimo
Oct 1, 1970·Archives of Neurology·M H Brooke, K K Kaiser
Dec 1, 1968·Clinica Chimica Acta; International Journal of Clinical Chemistry·R N WrightstoneA van der Sar
Nov 1, 1983·British Journal of Haematology·B E SerjeantG R Serjeant
Apr 1, 1981·Respiration Physiology·H HoppelerC R Taylor
Nov 1, 1981·American Journal of Hematology·E A O'RearE C Lynch
Sep 11, 1997·The New England Journal of Medicine·H F Bunn
May 20, 1998·Medicine and Science in Sports and Exercise·A BileJ Mercier
Dec 22, 1999·The American Journal of Physiology·K Parthasarathi, H H Lipowsky
Mar 31, 2000·Nature Medicine·P Carmeliet
Jun 24, 2000·Journal of Reproduction and Fertility·M H StoffelS H Hartmann
Apr 3, 2001·The Japanese Journal of Physiology·G McHedlishvili, N Maeda
Apr 24, 2002·Microvascular Research·Eric M BreyCharles W Patrick
Mar 12, 2003·Clinical Journal of Sport Medicine : Official Journal of the Canadian Academy of Sport Medicine·Fagnété SaraOlivier Hue
Jun 5, 2003·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Robert K. Pretzlaff
May 1, 1965·Virology·J P LEVYJ BERNARD
Oct 1, 2003·Vox Sanguinis·M M BrandãoM L Barjas-Castro
Nov 25, 2003·Seminars in Thrombosis and Hemostasis·Oguz K Baskurt, Herbert J Meiselman
Aug 11, 2004·European Journal of Heart Failure·Martin GaretFrédéric Roche
Aug 31, 2004·Journal of Applied Physiology·Barry M PriorRonald L Terjung
Jan 25, 2005·American Journal of Physiology. Heart and Circulatory Physiology·John D BelcherGregory M Vercellotti
Jul 15, 2005·Medicine and Science in Sports and Exercise·Géraldine MonchaninCyril Martin
Oct 4, 2005·European Journal of Internal Medicine·A A Leslie Ajayi
Mar 1, 2006·European Journal of Applied Physiology·Philippe ConnesOlivier Hue
Apr 6, 2006·Journal of Internal Medicine·S LehouxA Tedgui
Apr 14, 2006·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Geoffrey W Payne, Shawn E Bearden

❮ Previous
Next ❯

Citations

Jan 18, 2011·Hematology·Nigel S Key, Vimal K Derebail
May 17, 2014·Free Radical Biology & Medicine·Joshua T ButcherBrant E Isakson
Jun 4, 2015·Biophysical Journal·Etienne LoiseauManouk Abkarian
Sep 2, 2019·Histochemistry and Cell Biology·Nejc UmekIda Eržen
Jun 29, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Julien TripettePhilippe Connes
Apr 7, 2017·Journal of the American Heart Association·Anthony O EtyangThomas N Williams
Sep 20, 2018·BMC Neurology·Simone BirnbaumJean-Yves Hogrel
Jan 5, 2021·Current Sports Medicine Reports·E Randy Eichner
Aug 11, 2018·Medicine and Science in Sports and Exercise·Angèle N MerletLaurent A Messonnier
Aug 3, 2021·Experimental and Therapeutic Medicine·Jingwei Liu, Yumei Li
Oct 12, 2021·European Journal of Applied Physiology·K ReminyS Antoine-Jonville
Jun 11, 2011·Clinics in Sports Medicine·E Randy Eichner
May 3, 2019·Pediatric Emergency Care·Caroline Newman, Karl B Fields

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.