Remodeling of the Candida glabrata cell wall in the gastrointestinal tract affects the gut microbiota and the immune response

Scientific Reports
Rogatien CharletSamir Jawhara

Abstract

The gastrointestinal (GI) microbiota acts a natural barrier to the proliferation of opportunistic pathogens. Candida glabrata is an opportunistic yeast pathogen that has adapted to colonize all segments of the human GI tract. We observed an increase in Escherichia coli, Enterococcus faecalis, and Bacteroides vulgatus populations, and a decrease in Lactobacillus johnsonii, Bacteroides thetaiotaomicron, and Bifidobacterium animalis in mice with DSS-induced colitis. This reduction was more pronounced for L. johnsonii during C. glabrata overgrowth. In addition, C. glabrata overgrowth increased mouse mortality and inflammatory parameters, and modulated the expression of intestinal receptors and signaling pathways. The C. glabrata cell wall underwent various changes during the course of C. glabrata colonization, and showed a significant increase in chitin. C. glabrata deficient in chitin synthase-3 induced fewer inflammatory parameters than the parental strain during intestinal inflammation. Oral administration of chitin attenuated the impact of colitis, and reduced the number of aerobic bacteria and C. glabrata overgrowth, while chitinase-3-like protein-1 increased. This study provides evidence that inflammation of the gut alters th...Continue Reading

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Citations

Sep 22, 2018·Current Opinion in Gastroenterology·Irina LeonardiIliyan D Iliev
Jul 17, 2020·Expert Review of Anti-infective Therapy·Mubashshir RasheedRupinder Kaur
Aug 30, 2018·Frontiers in Microbiology·Prabhugouda SiriyappagouderViswanath Kiron
Nov 30, 2019·Frontiers in Cellular and Infection Microbiology·Jordan LeroySamir Jawhara
Feb 2, 2020·Digestive Diseases and Sciences·Akihiko Oka, R Balfour Sartor
May 24, 2019·Pathogens·Wibke KrügerMaria Joanna Niemiec
Dec 23, 2020·Microorganisms·Aly KodioStéphane Ranque
May 25, 2021·Critical Reviews in Food Science and Nutrition·José Carlos AndradeCélia F Rodrigues
Aug 27, 2021·Journal of Fungi·Yahaya HassanLeslie Thian Lung Than
Sep 28, 2021·Obesity Surgery·Andressa PradoTerezinha I E Svidzinski

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Methods Mentioned

BETA
flow cytometry
confocal
biopsies
confocal microscopy
nuclear magnetic resonance
PCR
ELISA

Software Mentioned

GraphPad Prism
XLSTAT

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