Remodeling of the radial artery in response to a chronic increase in shear stress

Hypertension
X GirerdS Laurent

Abstract

Chronic changes in large artery blood flow rates induce corresponding adjustments in arterial diameter, but little is known about structural adaptations of the vessel wall in humans. We used a high-resolution echo-tracking system to measure radial artery internal diameter, wall thickness, and mean blood flow on both arms of 11 patients with end-stage renal disease. Measurements were performed on the wrist side of the arteriovenous fistula. The contralateral radial artery was investigated as control. Wall cross-sectional area, circumferential wall stress, and mean wall shear stress were calculated. Results indicate a sixfold increase in blood flow on the side of the arteriovenous fistula compared with the control side, with a 1.4-fold increase in internal diameter. The diameter enlargement was sufficient to normalize wall shear stress. Changes in diameter were not associated with arterial wall hypertrophy because wall cross-sectional area was not increased and rather suggest a "remodeling" of the arterial wall. For the same level of blood pressure, circumferential wall stress was increased on the side of the arteriovenous fistula. These results suggest that the structural adaptations of the arterial wall to a chronic increase in...Continue Reading

References

Feb 1, 1991·Clinical Physics and Physiological Measurement : an Official Journal of the Hospital Physicists' Association, Deutsche Gesellschaft Für Medizinische Physik and the European Federation of Organisations for Medical Physics·Y TardyM Arditi
Apr 1, 1989·The American Journal of Physiology·B L LangilleF W Keeley
Jun 1, 1989·Hypertension·G L Baumbach, D D Heistad
Mar 1, 1987·Journal of Vascular Surgery·C K ZarinsS Glagov
Aug 1, 1974·Clinical Science and Molecular Medicine·M E SafarP L Milliez
Nov 1, 1983·Artificial Organs·J D BouthierM E Safar
Dec 1, 1994·American Journal of Hypertension·X GirerdS Laurent

❮ Previous
Next ❯

Citations

Sep 24, 2005·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·S RothS Horsch
Aug 5, 2005·Annals of Biomedical Engineering·Jason W NicholKeith J Gooch
Jul 17, 2008·Annals of Biomedical Engineering·J OrtegaD Maitland
Dec 26, 2001·Ultrasound in Medicine & Biology·S P SettyH G Beebe
Aug 27, 2005·Nature Clinical Practice. Cardiovascular Medicine·C J SlagerP W Serruys
Mar 1, 2003·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Armin Helisch, Wolfgang Schaper
Mar 21, 2002·Clinical and Experimental Pharmacology & Physiology·R JoannidesC Thuillez
Aug 11, 2000·Kidney International. Supplement·F MeeusG M London
Aug 18, 2010·Antioxidants & Redox Signaling·Amir RezvanHanjoong Jo
May 1, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Marc R ScheltingaCornelis Maria Adrianus Bruijninckx
Jul 21, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Bogdan Ene-Iordache, Andrea Remuzzi
Apr 5, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Carlo Basile, Carlo Lomonte
Apr 2, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Tonia C RothuizenJoris I Rotmans
Aug 16, 2012·Seminars in Dialysis·Ehsan Rajabi-JagahrghRupak K Banerjee
Jul 31, 2001·Journal of Biomechanical Engineering·B Ene-IordacheA Remuzzi
Feb 1, 2013·Journal of Biomechanical Engineering·Patrick M McGahAlberto Aliseda
Jul 13, 2006·Annual Review of Biomedical Engineering·Ghassan S Kassab, José A Navia
Jan 31, 2009·Journal of Applied Physiology·Marisa Garcia, Ghassan S Kassab
Mar 15, 2005·The Journal of Clinical Investigation·Michel AziziXavier Jeunemaitre
Apr 5, 2013·PloS One·William J KowalskiKerem Pekkan
Sep 17, 2013·Biomechanics and Modeling in Mechanobiology·Patrick M McGahAlberto Aliseda
Dec 1, 1999·Current Opinion in Cardiology·H B Barner, T M Sundt
Jan 14, 1999·Journal of Hypertension·G M LondonM E Safar
Nov 16, 2004·Journal of Vascular Research·Joost P G SluijterDominique P V de Kleijn
Jul 28, 2011·Kidney & Blood Pressure Research·Jun-Neng RoanChen-Fuh Lam
Dec 22, 2015·Archives of Biochemistry and Biophysics·Rachel D SimmonsHanjoong Jo
Jul 8, 2015·Neuroscience and Biobehavioral Reviews·Achim Peters, Bruce S McEwen
Aug 3, 2006·Kidney International·B S Dixon
Jun 1, 1997·Kidney International·G M London, T B Drueke
Apr 20, 2010·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·A K ChaniotisV Marmarellis
Jul 12, 2008·Atherosclerosis·J Karlijn van KeulenDominique P V de Kleijn
Nov 3, 2007·The Journal of Thoracic and Cardiovascular Surgery·Shinya FukuiYuji Miyamoto
Jun 5, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Marko Malovrh

❮ Previous
Next ❯

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