Remodelling of cardiac sympathetic re-innervation with thoracic spinal cord stimulation improves left ventricular function in a porcine model of heart failure

Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology
Song-Yan LiaoHung-Fat Tse

Abstract

Thoracic spinal cord stimulation (SCS) has been shown to improve left ventricular ejection fraction (LVEF) in heart failure (HF). Nevertheless, the optimal duration (intermittent vs. continuous) of stimulation and the mechanisms of action remain unclear. We performed chronic thoracic SCS at the level of T1-T3 (50 Hz, pulse width 0.2 ms) in 30 adult pigs with HF induced by myocardial infarction and rapid ventricular pacing for 4 weeks. All the animals were treated with daily oral metoprolol succinate (25 mg) plus ramipril (2.5 mg), and randomized to a control group (n = 10), intermittent SCS (4 h ×3, n = 10) or continuous SCS (24 h, n = 10) for 10 weeks. Serial measurements of LVEF and +dP/dt and serum levels of norepinephrine and B-type natriuretic peptide (BNP) were measured. After sacrifice, immunohistological studies of myocardial sympathetic and parasympathetic nerve sprouting and innervation were performed. Echocardiogram revealed a significant increase in LVEF and +dP/dt at 10 weeks in both the intermittent and continuous SCS group compared with controls (P < 0.05). In both SCS groups, there was diffuse sympathetic nerve sprouting over the infarct, peri-infarct, and normal regions compared with only the peri-infarct and i...Continue Reading

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Citations

Jan 10, 2016·JACC. Heart Failure·Gaurav A Upadhyay, Jagmeet P Singh
Feb 17, 2017·Pacing and Clinical Electrophysiology : PACE·Jan NaarMarcus Ståhlberg
Jun 10, 2017·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Neringa PauzieneDainius H Pauza
Sep 15, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Louis A SaddicAman Mahajan
Mar 15, 2019·Circulation Research·Lilian Grigorian ShamagianRoberto Bolli
Nov 7, 2015·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Ling-Chao YangYi-Gang Li
Oct 3, 2020·Biomolecules·Andreas SpannbauerMariann Gyöngyösi
Jun 7, 2017·JACC. Basic to Translational Science·Song-Yan LiaoHung-Fat Tse
Nov 28, 2017·Cardiac Electrophysiology Clinics·William A HuangMarmar Vaseghi

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