Remote allergen exposure elicits eosinophil infiltration into allergen nonexposed mucosal organs and primes for allergic inflammation.

Mucosal Immunology
Courtney L OlbrichLisa A Spencer

Abstract

The natural history of allergic diseases suggests bidirectional and progressive relationships between allergic disorders of the skin, lung, and gut indicative of mucosal organ crosstalk. However, impacts of local allergic inflammation on the cellular landscape of remote mucosal organs along the skin:lung:gut axis are not yet known. Eosinophils are tissue-dwelling innate immune leukocytes associated with allergic diseases. Emerging data suggest heterogeneous phenotypes of tissue-dwelling eosinophils contribute to multifaceted roles that favor homeostasis or disease. This study investigated the impact of acute local allergen exposure on the frequency and phenotype of tissue eosinophils within remote mucosal organs. Our findings demonstrate allergen challenge to skin, lung, or gut elicited not only local eosinophilic inflammation, but also increased the number and frequency of eosinophils within remote, allergen nonexposed lung, and intestine. Remote allergen-elicited lung eosinophils exhibited an inflammatory phenotype and their presence associated with enhanced susceptibility to airway inflammation induced upon subsequent inhalation of a different allergen. These data demonstrate, for the first time, a direct effect of acute all...Continue Reading

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Citations

Jul 29, 2020·Mucosal Immunology·Niki D Ubags
Oct 3, 2020·European Respiratory Review : an Official Journal of the European Respiratory Society·Niki D J UbagsJennifer J P Collins
Mar 28, 2021·Seminars in Immunopathology·G CoakleyN L Harris
Jul 6, 2021·Frontiers in Physiology·Xiaohua GuiMing D Li
Oct 10, 2021·Alimentary Pharmacology & Therapeutics·Mudar Zand IraniNicholas J Talley
Nov 17, 2021·PLoS Pathogens·Denise Silva NogueiraRicardo Toshio Fujiwara

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Methods Mentioned

BETA
flow cytometry
bronchoalveolar lavage

Software Mentioned

FlowJo

Related Concepts

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