Jun 2, 2020

Remote, Automated, and MRI-Compatible Administration of Interoceptive Inspiratory Resistive Loading

Frontiers in Human Neuroscience
Sebastian W RiegerOlivia K Harrison


Research on how humans perceive sensory inputs from their bodies ("interoception") has been rapidly gaining momentum, with interest across a host of disciplines from physiology through to psychiatry. However, studying interoceptive processes is not without significant challenges, and many methods utilized to access internal states have been largely devoted to capturing and relating naturally occurring variations in interoceptive signals (such as heartbeats) to measures of how the brain processes these signals. An alternative procedure involves the controlled perturbation of specific interoceptive axes. This is challenging because it requires non-invasive interventions that can be repeated many times within a subject and that are potent but safe. Here we present an effective methodology for instigating these perturbations within the breathing domain. We describe a custom-built circuitry that is capable of delivering inspiratory resistive loads automatically and precisely. Importantly, our approach is compatible with magnetic resonance imaging (MRI) environments, allowing for the administration of complicated experimental designs in neuroimaging as increasingly required within developing fields such as computational psychiatry/ps...Continue Reading

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Mentioned in this Paper

Experimental Design
Psychiatry Specialty
Body Structure
Drug Resistance
Heart Beat
Research Design
Magnetic Resonance Imaging
Monitoring - Action

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