Remote control of the permeability of the blood-brain barrier by magnetic heating of nanoparticles: A proof of concept for brain drug delivery

Journal of Controlled Release : Official Journal of the Controlled Release Society
Seyed Nasrollah TabatabaeiSylvain Martel

Abstract

Despite advances in neurology, drug delivery to the brain remains a substantial challenge. This is mainly due to the insurmountable and selective nature of the blood-brain barrier (BBB). In this study, we show that the thermal energy generated by magnetic heating (hyperthermia) of commercially available magnetic nanoparticles (MNPs) in the brain capillaries of rats can transiently increase barrier permeability. Here, the fluorescent Evans Blue (EB) dye was used to verify the BBB integrity. Results indicate a substantial but reversible opening of the BBB where hyperthermia is applied. Also, in this investigation, analysis of CD68 immunoreactivity, an indicator of inflammation, implies that this technique is not associated with any inflammation. We have previously investigated theranostic (therapeutic and diagnostic) capabilities of the MNPs, therefore, the findings presented in this investigation are particularly encouraging for a novel targeted drug delivery system to the brain.

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Citations

Feb 26, 2016·Neuropharmacology·Charissa PoonKullervo Hynynen
Jul 28, 2015·Nanomedicine·Seyed Nasrollah TabatabaeiSylvain Martel
Apr 25, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Kinam Park
Jul 14, 2016·Neuro-oncology·Geoff AppelboomOlivier Tillement
Feb 2, 2017·Drug Development and Industrial Pharmacy·Oscar Escalona-RayoDavid Quintanar-Guerrero
Apr 1, 2017·Therapeutic Delivery·Sylvain Martel
Dec 22, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Federico D'AgataCaterina Guiot
May 6, 2019·Nanomedicine·Alessandro FalconieriVittoria Raffa
Oct 10, 2019·Advanced Healthcare Materials·Ki-Won GyakDong-Pyo Kim
Nov 13, 2019·Biomedizinische Technik. Biomedical Engineering·André Gonçalves PrósperoJosé Ricardo de Arruda Miranda
Dec 5, 2019·Frontiers in Bioengineering and Biotechnology·Michele d'AngeloAnnamaria Cimini
May 28, 2020·Pathogens·Hany M ElsheikhaNaveed Ahmed Khan
Dec 11, 2015·Nanomaterials·Maria Antònia BusquetsJoan Estelrich
Jul 6, 2016·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Seyed Nasrollah TabatabaeiSylvain Martel
Aug 7, 2018·Contrast Media & Molecular Imaging·Tang TangMarc Dhenain
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Jan 8, 2016·Neurophotonics·Depeng WangJun Xia
Apr 27, 2018·Frontiers in Systems Neuroscience·Mattia BraminiFabrizia Cesca
Oct 4, 2020·Biosensors & Bioelectronics·Shuangjie LiuDong Ming
Jan 11, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Liron L IsraelJulia Y Ljubimova
Jan 15, 2021·Biomedical Physics & Engineering Express·Gioia LucariniArianna Menciassi
Jan 27, 2020·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Maria Inês TeixeiraPaulo C Costa
Mar 9, 2021·Advanced Materials·Pingping LiangXiaochen Dong
Jun 20, 2021·Advanced Drug Delivery Reviews·Lingxiao ZhangFangyuan Li
Jul 31, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Marjan TalebiSaeed Samarghandian
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Dec 21, 2021·Advanced Science·Yichao YuMark F Lythgoe

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