Remote efficacy for two different forms of hyaluronate-based adhesion barriers

Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research
Keith E GreenawaltThomas H Jozefiak

Abstract

Chemically modified sodium hyaluronate and carboxymethylcellulose (HA/CMC) membrane clinically reduces adhesion formation following surgery but was not designed for laparoscopic use. HA/CMC powder of identical chemical composition has been developed to allow for application laparoscopically. We compared the adhesion reduction efficacy of HA/CMC powder and film when applied directly to or remote from sites of surgical trauma. We also investigated the effect of the powder on wound healing. Two animal models of adhesion formation were used to evaluate efficacy: a rat peritoneal sidewall defect model and a rabbit cecal abrasion/sidewall defect model. The products were applied directly to the defect or the contralateral sidewall. Adhesions were examined seven days after surgery. In a separate study, the effect of the powder on healing was evaluated at 5, 7, and 28 days using a rat incisional wound strength model. HA/CMC powder and film, when applied directly to the peritoneal defect, significantly reduced adhesions relative to the untreated control in both models. Remote applications of HA/CMC powder also reduced adhesions. In contrast, remote applications of HA/CMC film had no effect. HA/CMC powder did not significantly alter incis...Continue Reading

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Citations

May 8, 2014·World Journal of Gastroenterology : WJG·Valerio Mais
Mar 5, 2014·Langenbeck's Archives of Surgery·Bernhard W RenzReinhold A Lang
Mar 22, 2013·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Gregory ChristodoulidisKonstantinos Tepetes
Apr 18, 2013·The British Journal of Surgery·A A ChaturvediH van Goor
Nov 10, 2015·BioMed Research International·Timothy BowenThomas Sitter
Mar 22, 2013·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Taufiek Konrad RajabMarkus Wallwiener
Apr 29, 2014·The Journal of Surgical Research·Atsushi OhataHiroshi Nojima
Feb 4, 2014·Biomedical Materials·Kyung Eun YouJong-Chul Park

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