Remote ischaemic conditioning and healthcare system delay in patients with ST-segment elevation myocardial infarction

Heart
Kasper PrydsCONDI Investigators

Abstract

We investigated influence of remote ischaemic conditioning (RIC) on the detrimental effect of healthcare system delay on myocardial salvage in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (pPCI). A post-hoc analysis of a randomised controlled trial in patients with STEMI randomised to treatment with pPCI or RIC+pPCI. RIC was performed as four cycles of intermittent 5 min upper arm ischaemia and reperfusion. Healthcare system delay was defined as time from emergency medical service call to pPCI-wire. Myocardial salvage index (MSI) was assessed by single photon emission computerised tomography. Data for healthcare system delay and MSI were available for 129 patients. MSI was negatively associated with healthcare system delay in patients treated with pPCI alone (-0.003 decrease in MSI/min of healthcare system delay; 95% CI -0.005 to -0.001, r(2)=0.11, p=0.008) but not in patients treated with RIC+pPCI (-0.0002 decrease in MSI/min of healthcare system delay; 95% CI -0.001 to 0.001, r(2)=0.002, p=0.74). In patients with healthcare system delay ≤120 min, RIC+pPCI did not affect median MSI compared with pPCI alone (0.75 (IQR: 0.49-0.99) and 0.70 (0.45-0.94), p=1...Continue Reading

Associated Clinical Trials

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Citations

Jul 6, 2016·International Journal of Cardiology·Xavier Rossello, Derek M Yellon
Sep 21, 2016·Expert Opinion on Drug Safety·Engi Abdel-Hady AlgharablyReinhold Kreutz
Apr 7, 2017·Journal of Cardiovascular Pharmacology and Therapeutics·Michael Rahbek SchmidtHans Erik Bøtker
Jun 21, 2017·Journal of Cardiovascular Pharmacology and Therapeutics·Kirk N Garratt, Boris Leschinsky
Mar 3, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Hans Erik BøtkerNichlas Riise Jespersen
Jun 27, 2018·European Heart Journal·Manuel Lobo, Borja Ibanez
Apr 14, 2018·Circulation Research·Xavier Rossello, Borja Ibanez
Apr 30, 2017·Circulation Research·Gerd Heusch
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Apr 27, 2020·Basic Research in Cardiology·Derek J HausenloyDerek M Yellon
May 26, 2018·Journal of Cardiovascular Translational Research·John H RosenbergDevendra K Agrawal
Apr 3, 2019·Basic Research in Cardiology·Georgios AmanakisAndreas Skyschally
Jul 1, 2020·Journal of Cardiovascular Pharmacology and Therapeutics·Hans Erik Bøtker
Sep 19, 2020·Interventional Cardiology·Joel P Giblett, Heerajnarain Bulluck
Jan 27, 2021·Basic Research in Cardiology·Hans Erik Bøtker

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