Remote ischemic conditioning for acute stroke patients treated with thrombectomy

Annals of Clinical and Translational Neurology
Wenbo ZhaoXunming Ji

Abstract

Remote ischemic conditioning (RIC) has been demonstrated to be safe and feasible for patients with acute ischemic stroke (AIS), as well as for those receiving intravenous thrombolysis. We assessed the safety and feasibility of RIC for AIS patients undergoing endovascular treatment (ET). We conducted a pilot study with patients with AIS who were suspected of having an emergent large-vessel occlusion in the anterior circulation and who were scheduled for ET within 6 hours of ictus. Four cycles of RIC were performed before recanalization, immediately following recanalization, and once daily for the subsequent 7 days. The primary outcome was any serious RIC-related adverse events. Twenty subjects, aged 66.1 ± 12.1 years, were recruited. No subject experienced serious RIC-related adverse events. The intracranial pressure, cranial perfusion pressure, mean arterial pressure, heart rate, middle cerebral artery peak systolic flow velocity, and pulsatility index did not change significantly before, during, or after the limb ischemia (P > 0.1 for all). Of 80 cycles, 71 (89%) were completed before recanalization and 80 (100%) were completed immediately after recanalization; 444 of 560 cycles (78%) were completed within 7 days posttreatment...Continue Reading

References

Sep 26, 2008·The New England Journal of Medicine·Werner HackeUNKNOWN ECASS Investigators
Mar 19, 2011·Stroke; a Journal of Cerebral Circulation·Sebastian KochMiguel Perez-Pinzon
Nov 10, 2013·Stroke; a Journal of Cerebral Circulation·Kristina Dupont HougaardGrethe Andersen
Jul 16, 2014·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Enjarn LinPaul S Myles
Jan 2, 2015·Dose-response : a Publication of International Hormesis Society·Roger Simon
Jun 13, 2015·Lancet Neurology·Marc Fisher, Jeffrey L Saver
Feb 19, 2016·Stroke; a Journal of Cerebral Circulation·Bruce C V CampbellMayank Goyal
May 20, 2017·Journal of the American Heart Association·Eva A MistryJohn J Volpi
Aug 11, 2017·Stroke; a Journal of Cerebral Circulation·Marcelo Rocha, Tudor G Jovin
Oct 1, 2017·Journal of Neurointerventional Surgery·Thabele Leslie-MazwiUNKNOWN Standards and Guidelines committee of the Society of NeuroInterventional Surgery (SNIS)
Nov 14, 2017·The New England Journal of Medicine·Raul G NogueiraUNKNOWN DAWN Trial Investigators
Nov 18, 2017·Stroke; a Journal of Cerebral Circulation·Sean I SavitzMarc Fisher
Jan 25, 2018·The New England Journal of Medicine·Gregory W AlbersUNKNOWN DEFUSE 3 Investigators

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Citations

Apr 4, 2019·The Neuroradiology Journal·Seyed Mohammad SeyedsaadatDavid F Kallmes
Jun 4, 2019·Stroke; a Journal of Cerebral Circulation·Thijs R J LandmanDick H J Thijssen
Nov 22, 2019·Journal of the American Heart Association·Timothy J EnglandPhilip M Bath
Nov 22, 2019·Journal of the American Heart Association·Amir Shaban, Enrique C Leira
Jan 19, 2019·Annals of Clinical and Translational Neurology·Wenbo ZhaoXunming Ji
Mar 9, 2019·Annals of Clinical and Translational Neurology·Ruiwen CheXunming Ji
Nov 21, 2020·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Jason P AppletonTimothy J England
Jan 7, 2021·American Journal of Physiology. Lung Cellular and Molecular Physiology·Anthony V IncognitoW Glen Pyle
Apr 28, 2021·Stroke and Vascular Neurology·Sheharyar BaigAli Ali
Jun 17, 2021·Annals of Clinical and Translational Neurology·Line Fuglsang HansenChristina Kruuse

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Clinical Trials Mentioned

NCT03210051
NCT03045055

Software Mentioned

SPSS

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