Remote ischemic conditioning in ST-elevation myocardial infarction as adjuvant to primary angioplasty (RIC-STEMI): study protocol for a randomized controlled trial

Trials
António GasparAdelino F Leite-Moreira

Abstract

ST-elevation myocardial infarction (STEMI) accounts for nearly one third of acute coronary syndromes. Despite improved STEMI patient care, mortality remains high, contributing significantly to the ischemic heart disease burden. This may partly be related to ischemia-reperfusion injury (IRI). Remote ischemic conditioning (RIC), through short cycles of ischemia-reperfusion applied to a limb, has been shown to reduce IRI in various clinical settings. Our primary hypothesis is that RIC will reduce adverse events related to STEMI when applied as adjunctive therapy to primary percutaneous coronary intervention (PCI). "Remote ischemic conditioning in ST-elevation myocardial infarction as adjuvant to primary angioplasty" (RIC-STEMI) is an ongoing prospective, single-center, open-label, randomized controlled trial to assess whether RIC as an adjunctive therapy during primary PCI in patients presenting with STEMI can improve clinical outcomes. After enrollment, participants are randomized according to a computer-generated randomization schedule, in a ratio of 1:1 to RIC or no intervention, in blocks of four individuals. RIC is begun at least 10 min before the estimated time of the first balloon inflation and its duration is 30 min. Ische...Continue Reading

References

Feb 20, 2007·Cardiovascular Research·Maurits T DirksenDirk J G M Duncker
Sep 15, 2007·The New England Journal of Medicine·Derek M Yellon, Derek J Hausenloy
Feb 20, 2008·Annals of Internal Medicine·Isabelle BoutronUNKNOWN CONSORT Group
Mar 25, 2010·BMJ : British Medical Journal·Kenneth F SchulzUNKNOWN CONSORT Group
Jan 11, 2013·BMJ : British Medical Journal·An-Wen ChanDavid Moher
Mar 29, 2013·European Heart Journal·Georg M FröhlichDerek J Hausenloy
Jan 17, 2015·Journal of the American College of Cardiology·Gerd HeuschDerek Yellon
Apr 11, 2015·Journal of the American College of Cardiology·Borja IbáñezFrans Van de Werf

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BETA
coronary artery bypass

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