Remote ischemic conditioning temporarily improves antioxidant defense

The Journal of Surgical Research
Felipe Lobato da Silva CostaSandro Percário

Abstract

Remote ischemic conditioning (RIC) is the most promising surgical approach to mitigate ischemia and reperfusion (IR) injury. It consists in performing brief cycles of IR in tissues other than those exposed to ischemia. The underlying mechanisms of the induced protection are barely understood, so we evaluated if RIC works enhancing the antioxidant defense of the liver and kidney before IR injury. Twenty-one Wistar rats were assigned into three groups as follows: sham, same surgical procedure as in the remaining groups was performed, but no RIC was carried out. RIC 10, RIC was performed, and no abdominal organ ischemia was induced. After 10 min of the end of the RIC protocol, the liver and kidney were harvested. RIC 60, similar procedure as performed in RIC 10, but the liver and the kidney were harvested 60 min. RIC consisted of three cycles of 5-min left hind limb ischemia followed by 5-min left hind limb perfusion, lasting 30 min in total. Samples were used to measure tissue total antioxidant capacity. RIC protocol increased both liver (1.064 ± 0.26 mM/L) and kidney (1.310 ± 0.17 mM/L) antioxidant capacity after 10 min when compared with sham (liver, 0.759 ± 0.10 mM/L and kidney, 1.08 ± 0.15 mM/L). Sixty minutes after the RIC p...Continue Reading

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Oct 1, 2014·The Journal of Surgical Research·Zoltán CzigányAttila Szijártó

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Citations

Apr 14, 2017·Acta Cirúrgica Brasileira·Marcus Vinicius Henriques BritoHellen Aparecida Geyer Dos Santos
Apr 14, 2017·Acta Cirúrgica Brasileira·Rita de Cássia Silva de OliveiraHigor Yuri Bezerra Henriques
Dec 17, 2016·Revista do Colégio Brasileiro de Cirurgiões·Igor Nagai YamakiMarcus Vinicius Henriques Brito
Jul 24, 2018·Brain Injury : [BI]·Yingli WangZhiqiang Shen
Apr 30, 2020·Acta Cirúrgica Brasileira·Ananda Vitória Barros Suzuki DamascenoHigor Yuri Bezerra Henriques
Sep 14, 2017·Acta Cirúrgica Brasileira·Felipe Lobato da Silva CostaMarcus Vinicius Henriques Brito
Oct 12, 2017·Arquivos Brasileiros De Cirurgia Digestiva : ABCD = Brazilian Archives of Digestive Surgery·Carlos Henrique Marques Dos SantosJoão Victor Cunha Miranda
Feb 4, 2021·Acta Cirúrgica Brasileira·Edson Yuzur YasojimaSérgio Cunha Trindade Júnior
Jun 29, 2021·Jornal Vascular Brasileiro·Felipe Lobato da Silva CostaMarcus Vinicius Henriques Brito

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