Remote Ischemic Perconditioning to Reduce Reperfusion Injury During Acute ST-Segment-Elevation Myocardial Infarction: A Systematic Review and Meta-Analysis

Journal of the American Heart Association
Shelley L McLeodSheldon Cheskes

Abstract

Remote ischemic conditioning (RIC) is a noninvasive therapeutic strategy that uses brief cycles of blood pressure cuff inflation and deflation to protect the myocardium against ischemia-reperfusion injury. The objective of this systematic review was to determine the impact of RIC on myocardial salvage index, infarct size, and major adverse cardiovascular events when initiated before catheterization. Electronic searches of Medline, Embase, and Cochrane Central Register of Controlled Trials were conducted and reference lists were hand searched. Randomized controlled trials comparing percutaneous coronary intervention (PCI) with and without RIC for patients with ST-segment-elevation myocardial infarction were included. Two reviewers independently screened abstracts, assessed quality of the studies, and extracted data. Data were pooled using random-effects models and reported as mean differences and relative risk with 95% confidence intervals. Eleven articles (9 randomized controlled trials) were included with a total of 1220 patients (RIC+PCI=643, PCI=577). Studies with no events were excluded from meta-analysis. The myocardial salvage index was higher in the RIC+PCI group compared with the PCI group (mean difference: 0.08; 95% co...Continue Reading

References

Sep 1, 1990·Circulation·R Bolli
Nov 1, 1985·The Journal of Clinical Investigation·E Braunwald, R A Kloner
Sep 2, 1993·The New England Journal of Medicine·UNKNOWN GUSTO investigators
Dec 8, 2000·Italian heart journal. Supplement : official journal of the Italian Federation of Cardiology·G Bernardi
Dec 18, 2001·Cardiovascular Research·Nikolaos G FrangogiannisMark L Entman
Jun 5, 2003·Circulation·Paul W ArmstrongElliott Antman
Sep 19, 2003·Journal of the American College of Cardiology·Giuseppe De LucaUNKNOWN ZWOLLE Myocardial Infarction Study Group
Jun 19, 2004·BMJ : British Medical Journal·David AtkinsUNKNOWN GRADE Working Group
Sep 15, 2007·The New England Journal of Medicine·Derek M Yellon, Derek J Hausenloy
Jul 13, 2012·Circulation Journal : Official Journal of the Japanese Circulation Society·Tuncay YetginWim J van der Giessen
Feb 14, 2013·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Rashed M AhmedTahir I Mohamed
Feb 19, 2013·The Canadian Journal of Cardiology·Sheng Jie LuoRui Fang Liu
Aug 3, 2013·Circulation Research·Michel OvizeKarin Przyklenk
Feb 26, 2014·The American Journal of Medicine·Vladimir ManchurovAlexander Shpektor
Jul 1, 2014·World Journal of Cardiology·Michael Rahbek SchmidtHans Erik Bøtker
Jan 17, 2015·Journal of the American College of Cardiology·Gerd HeuschDerek Yellon
Oct 6, 2015·The New England Journal of Medicine·Patrick MeybohmUNKNOWN RIPHeart Study Collaborators
Dec 17, 2015·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Michael WalshUNKNOWN Remote IMPACT Investigators
Aug 24, 2016·Circulation·Xavier Rossello, Derek M Yellon

❮ Previous
Next ❯

Citations

Mar 13, 2018·British Journal of Hospital Medicine·Haidi WuLing Qin
Oct 19, 2017·Biomarkers in Medicine·Christoph SinningPeter Clemmensen
Dec 12, 2019·Journal of Cardiovascular Pharmacology and Therapeutics·Robert A KlonerLifu Zhao
May 29, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Xuan LiuXiaoying Wang
Jun 29, 2021·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Alessandro Rodrigo BelonUenis Tannuri
Oct 31, 2020·European Journal of Pharmacology·Li-Ning WuJun-Ma Yu

❮ Previous
Next ❯

Methods Mentioned

BETA
coronary artery bypass

Software Mentioned

PubMed
RevMan
Ovid
GRADEpro
Review Manager

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.