Remote ischemic preconditioning delays the onset of acute mountain sickness in normobaric hypoxia

Physiological Reports
Marc M BergerHeimo Mairbäurl

Abstract

Acute mountain sickness (AMS) is a neurological disorder occurring when ascending too fast, too high. Remote ischemic preconditioning (RIPC) is a noninvasive intervention protecting remote organs from subsequent hypoxic damage. We hypothesized that RIPC protects against AMS and that this effect is related to reduced oxidative stress. Fourteen subjects were exposed to 18 hours of normoxia (21% oxygen) and 18 h of normobaric hypoxia (12% oxygen, equivalent to 4500 m) on different days in a blinded, randomized order. RIPC consisted of four cycles of lower limb ischemia (5 min) and 5 min of reperfusion, and was performed immediately before the study room was entered. A control group was exposed to hypoxia (12% oxygen, n = 14) without RIPC. AMS was evaluated by the Lake Louise score (LLS) and the AMS-C score of the Environmental Symptom Questionnaire. Plasma concentrations of ascorbate radicals, oxidized sulfhydryl (SH) groups, and electron paramagnetic resonance (EPR) signal intensity were measured as biomarkers of oxidative stress. RIPC reduced AMS scores (LLS: 1.9 ± 0.4 vs. 3.2 ± 0.5; AMS-C score: 0.4 ± 0.1 vs. 0.8 ± 0.2), ascorbate radicals (27 ± 7 vs. 65 ± 18 nmol/L), oxidized SH groups (3.9 ± 1.4 vs. 14.3 ± 4.6 μmol/L), and EP...Continue Reading

References

Jan 23, 1969·The New England Journal of Medicine·I SinghC S Subramanyam
Nov 1, 1996·Circulation·B C GhoP D Verdouw
Feb 1, 1997·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M A Pérez-PinzónT J Sick
Nov 25, 2000·Circulation Research·R Bolli
Mar 17, 2001·High Altitude Medicine & Biology·D M Bailey, B Davies
Dec 4, 2002·Circulation·R K KharbandaR MacAllister
Jun 13, 2003·Lancet·Buddha Basnyat, David R Murdoch
Nov 25, 2003·The Journal of Pharmacology and Experimental Therapeutics·John A AuchampachGarrett J Gross
Oct 23, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Steen B KristiansenHans Erik Bøtker
Nov 3, 2004·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Guohu LiGuro Valen
Jun 17, 2005·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Damian M BaileyPeter Bärtsch
Sep 12, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Roberto Bolli
Mar 11, 2009·QJM : Monthly Journal of the Association of Physicians·J K BaillieD J Webb
Mar 31, 2009·High Altitude Medicine & Biology·Marc M BergerErik R Swenson
Dec 1, 2012·Current Opinion in Neurology·Srinivasan V NarayananMiguel A Perez-Pinzon
Apr 9, 2013·Pharmacological Reports : PR·Anna GorącaBeata Skibska
Apr 20, 2013·Stroke; a Journal of Cerebral Circulation·Sebastian Koch, Nestor Gonzalez
Jun 14, 2013·The New England Journal of Medicine·Peter Bärtsch, Erik R Swenson
Mar 20, 2014·Circulation Research·Tienush RassafMalte Kelm
Jun 28, 2014·High Altitude Medicine & Biology·Gabriel WillmannPeter Bärtsch
Jun 28, 2014·High Altitude Medicine & Biology·Philip N Ainslie, Andrew W Subudhi

❮ Previous
Next ❯

Citations

Jan 12, 2016·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Wesley K LeffertsKevin S Heffernan
May 9, 2015·High Altitude Medicine & Biology·Bengt Kayser
Aug 13, 2015·Physiological Reports·Gaurav Sikri, Anuj Chawla
Apr 28, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Asmaa M Almohanna, Susan Wray
Feb 10, 2018·European Journal of Applied Physiology·Stefan De SmetPeter Hespel
Jun 20, 2015·Journal of Applied Physiology·Marc Moritz BergerPeter Bärtsch
Aug 12, 2017·Journal of Applied Physiology·Marc M BergerHeimo Mairbäurl
May 9, 2015·Journal of Applied Physiology·Robert Meller, Roger P Simon
Aug 25, 2019·International Journal of Molecular Sciences·Heimo MairbäurlMarc M Berger

❮ Previous
Next ❯

Software Mentioned

SigmaStat
Microcal Origin
SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.