Remote Left Ventricular Hemodynamic Monitoring Using a Novel Intracardiac Sensor

Circulation. Cardiovascular Interventions
Thomas MondritzkiHubert Truebel

Abstract

Heart failure (HF) remains the most common reason for hospital admission in patients aged >65 years. Despite modern drug therapy, mortality and readmission rates for patients hospitalized with HF remain high. This necessitates further research to identify early patients at risk for readmission to limit hospitalization by timely adjustment of medical therapy. Implantable devices can monitor left ventricular (LV) hemodynamics and remotely and continuously detect the early signs of decompensation to trigger interventions and reduce the risk of hospitalization for HF. Here, we report the first preclinical study validating a new batteryless and easy to implant LV-microelectromechanical system to assess LV performance. A miniaturized implantable wireless pressure sensor was adapted for implantation in the LV apex. The LV-microelectromechanical system sensor was tested in a canine model of HF. The wireless pressure sensor measurements were compared with invasive left heart catheter-derived measurements at several time points. During different pharmacological challenge studies with dobutamine or vasopressin, the device was equally sensitive compared with invasive standard procedures. No adverse events or any observable reaction related...Continue Reading

References

May 22, 2007·The American Journal of Cardiology·Li Wang
Oct 10, 2007·Veterinary Research Communications·F A Recchia, V Lionetti
Aug 19, 2007·Heart·Arend Mosterd, Arno W Hoes
Mar 18, 2008·Journal of the American College of Cardiology·Robert C BourgeUNKNOWN COMPASS-HF Study Group
Apr 3, 2009·The New England Journal of Medicine·Stephen F JencksEric A Coleman
Oct 8, 2009·Circulation. Heart Failure·Jennifer A Dixon, Francis G Spinale
Dec 19, 2009·Circulation·UNKNOWN WRITING GROUP MEMBERSUNKNOWN American Heart Association Statistics Committee and Stroke Statistics Subcommittee
Feb 24, 2010·Circulation·Jay RitzemaUNKNOWN Hemodynamically Guided Home Self-Therapy in Severe Heart Failure Patients (HOMEOSTASIS) Study Group
Nov 18, 2010·The New England Journal of Medicine·Sarwat I ChaudhryHarlan M Krumholz
Feb 15, 2011·Lancet·William T AbrahamUNKNOWN CHAMPION Trial Study Group
Apr 26, 2013·Circulation. Heart Failure·Paul A HeidenreichUNKNOWN Stroke Council
Apr 18, 2015·Journal of the American College of Cardiology·Reinoud E KnopsVivek Y Reddy
May 12, 2015·European Journal of Heart Failure·Hassan KhanUNKNOWN EVEREST Trial Investigators
Dec 15, 2015·European Journal of Heart Failure·Nathaniel M HawkinsAndrew D Krahn
Apr 4, 2016·International Journal of Cardiology·Antoine Da CostaKarl Isaaz
May 14, 2016·European Heart Journal·Eugenio Picano, Patricia A Pellikka
Sep 17, 2016·European Journal of Heart Failure·Philip B AdamsonWilliam T Abraham

❮ Previous
Next ❯

Citations

Aug 29, 2018·Sensors·Natiely Hernández-SebastiánWilfrido Calleja-Arriaga
May 12, 2018·Circulation. Cardiovascular Interventions·Kiyotake Ishikawa
Dec 30, 2021·JAMA Cardiology·Peter J KennelNir Uriel

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.