Remote neuroimmune signaling: a long-range mechanism of nociceptive network plasticity

Trends in Neurosciences
Carl Y Saab, Bryan C Hains

Abstract

Chronic pain secondary to neuronal injury is actively and continuously modulated at multiple locations along the sensory neuraxis. Here, we describe how nociceptive neurons of the spinal cord and thalamus process and communicate nociceptive information in terms of precisely calibrated firing patterns. We then discuss how several cell types with immunogenic properties (e.g. blood cells and glia) cause system-wide interference in nociceptive processing through novel signaling schema, thus contributing to nociceptive network plasticity and chronic pain.

References

Jan 20, 1997·The Journal of Comparative Neurology·P G PopovichB T Stokes
Aug 5, 1997·Proceedings of the National Academy of Sciences of the United States of America·C L CoxD A Prince
Jun 3, 2000·Nitric Oxide : Biology and Chemistry·K K Kopec, R T Carroll
Dec 13, 2000·Neuroscience·N M Perkins, D J Tracey
Jan 30, 2002·Frontiers in Bioscience : a Journal and Virtual Library·Trevor Owens, Alicia Babcock
Oct 26, 2002·Science·Michael L Dustin, David R Colman
Mar 5, 2003·Trends in Immunology·Jean Nicolas Tournier, Anne Quesnel Hellmann
May 3, 2003·Methods : a Companion to Methods in Enzymology·Violetta Zujovic, Veronique Taupin
May 3, 2003·Methods : a Companion to Methods in Enzymology·E A Eugenin, Joan W Berman
Dec 5, 2003·Nature Reviews. Drug Discovery·Linda R Watkins, Steven F Maier
Jan 22, 2004·Nature Reviews. Neuroscience·Mircea Steriade
Dec 8, 2004·The American Journal of Pathology·Cecilia L SpeyerPeter A Ward
Jun 25, 2005·Anesthesia and Analgesia·Aldric T Hama, David Borsook
Aug 19, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Eiko K de JongKnut Biber
Oct 15, 2005·Nature Reviews. Drug Discovery·Fletcher A WhiteRichard J Miller
Nov 4, 2005·Experimental Neurology·Charles H Hubscher, Richard D Johnson
Feb 24, 2006·Trends in Neurosciences·Stephen G Waxman, Bryan C Hains
Feb 25, 2006·Nature Reviews. Immunology·Carl Nathan
Apr 21, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Bryan C Hains, Stephen G Waxman
Jul 18, 2006·FEBS Letters·Samuel A Owolabi, Carl Y Saab
Nov 30, 2006·Brain, Behavior, and Immunity·Guillermo M AlexanderRobert J Schwartzman
Dec 7, 2006·Pain Practice : the Official Journal of World Institute of Pain·Jin Mo Chung, Kyungsoon Chung
Jan 24, 2007·The Journal of Experimental Medicine·Camilla I SvenssonCharles N Serhan
Mar 3, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Peng ZhaoBryan C Hains
Jun 1, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Wei GuoKe Ren
Jul 4, 2007·Neurology·Nurcan UçeylerClaudia Sommer
Aug 11, 2007·Trends in Immunology·Rafael FrancoPeta J O'Connell
Aug 19, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Peng ZhaoBryan C Hains
Oct 30, 2007·Nature Neuroscience·Joachim Scholz, Clifford J Woolf

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Citations

Nov 24, 2011·Pain Research and Treatment·Mark S Cooper, Adam S Przebinda
Jun 12, 2012·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Carl Saab
Aug 28, 2012·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Mark S Cooper, Vincent P Clark
Nov 29, 2012·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·C LinnmanD Borsook
Jul 6, 2012·Trends in Neurosciences·Carl Y Saab
Sep 12, 2009·The Journal of Pain : Official Journal of the American Pain Society·Yu-Wen ChangStephen Waxman
May 16, 2014·European Journal of Pain : EJP·S van GorpJ Patijn
Dec 3, 2014·Neuroscience Letters·Andrew M Tan, Stephen G Waxman
Jun 14, 2016·Neuroscience Letters·Marek JoukalPetr Dubový
May 30, 2020·International Journal of Molecular Sciences·Stefanie Hoffmann, Cordian Beyer
Jan 20, 2020·Cellular and Molecular Neurobiology·Jonghoon KangYoung S Gwak

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