Removal of acetylaminofluorene from the DNA of control and repair-deficient human fibroblasts

Ataxia telangiectasia is a rare neurodegenerative diseases caused by defects in the ATM gene, which is involved in DNA damage recognition and repair pathways. Here is the latest research on this autosomal recessive disease.

Removal of acetylaminofluorene from the DNA of control and repair-deficient human fibroblasts

Abstract

References

Induction by alkylating agents of sister chromatid exchanges and chromatid breaks in Fanconi's anemia

Deficiency of gamma-ray excision repair in skin fibroblasts from patients with Fanconi's anemia

Is Fanconi's anaemia defective in a process essential to the repair of DNA cross links?

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8-(N-2-fluorenylacetamido)guanosine, an arylamidation reaction product of guanosine and the carcinogen N-acetoxy-N-2-fluorenylacetamide in neutral solution

Incomplete momentum transfer in the 40Ar+58Ni reaction

Citations

Genetic and biochemical studies with ataxia telangiectasia. A review

Comparison of DNA-incising capacities in fibroblast strains from the Mannheim XP collection after treatment with N-acetoxy-2-acetylaminofluorene and UV light

DNA repair enzymes in ataxia telangiectasia and Bloom's syndrome fibroblasts

Excision repair in Drosophila. Analysis of strand breaks appearing in DNA of mei-9 mutants following mutagen treatment

Relationship between the covalent binding of N-acetoxy-2-acetylaminofluorene to DNA and a steroidal esterase activity in human mononuclear leukocytes

Induction of 6-thioguanine resistance in human cells treated with N-acetoxy-2-acetylaminofluorene

Anthramycin-induced sister-chromatid exchange and caffeine potentiation in the chromosomes of Indian muntjac

Direct comparison, in humans resting lymphocytes, of the inter-individual variations in unscheduled DNA synthesis induced by N-acetoxy-2-acetylaminofluorene and ultraviolet irradiation

DNA repair assays as tests for environmental mutagens. A report of the U.S. EPA Gene-Tox Program

Genetic toxicity of 2-acetylaminofluorene, 2-aminofluorene and some of their metabolites and model metabolites

Co-recessive inheritance: a model for DNA repair, genetic disease and carcinogenesis

Differences in removal of acetylaminofluorene and pyrimidine dimers from the DNA of cultured mammalian cells

The sensitivity of human fibroblasts to N-acetoxy-2-acetylaminofluorene is determined by the extent of transcription-coupled repair, and/or their capability to counteract RNA synthesis inhibition

Levels of DNA polymerases alpha, beta, and gamma in control and repair-deficient human diploid fibroblasts 1

The distribution of DNA repair synthesis in chromatin and its rearrangement following damage with N-acetoxy-2-acetylaminofluorene

Complementation studies between Fanconi's anemia cells with different DNA repair characteristics

Complementation of the xeroderma pigmentosum DNA repair defect in cell-free extracts

DNA repair in lymphoblastoid cell lines established from human genetic disorders

Immunocytological detection of AAF-DNA adducts in HeLa cell nuclei

DNA repair in Syrian hamster embryo cells treated with 7,12-dimethylbenz[a]anthracene and its weakly carcinogenic 5-fluoro analog

Metabolism of carcinogenic amino derivatives in various species and DNA alkylation by their metabolites

Influence of nucleotide excision repair on N-hydroxy-2-acetylaminofluorene-induced mutagenesis studied in lambda lacZ-transgenic mice

Repair deficient human disorders and cancer

N-Acetoxy-acetylaminofluorene reacts preferentially with a control region of intracellular SV40 chromosome

DNA repair and mutagenesis in mammalian cells

Lack of transcription-coupled repair of acetylaminofluorene DNA adducts in human fibroblasts contrasts their efficient inhibition of transcription.

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Ataxia telangiectasia (MDS)

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