Abstract
A few bedside polyester white cell (WBC)-reduction filters have been shown to scavenge C3a anaphylatoxin from stored blood components. One has been shown to remove the chemokines interleukin (IL)-8 and RANTES, but not the proinflammatory cytokines IL-1, IL-6, and tumor necrosis factor alpha. Removal by any filter of the anaphylatoxin C5a or the soluble membrane attack complex (SC5b-9) has not been studied. Further, the ability of other filters to scavenge these biologic response modifiers (BRM) is not known. Four WBC-reduction filters and one plasma filter were studied for their ability to remove IL-8, RANTES, IL-1 beta, C3a, C5a, and SC5b-9. Plasma was obtained either as freshly thawed fresh-frozen plasma, fresh-frozen plasma thawed and stored for 5 days, or platelet-poor supernatant. Cell-poor plasma was obtained and samples were taken before and after filtration through the various filters Levels of IL-1 beta, IL-8, RANTES, C3a, and SC5b9 were quantitated by enzyme immunoassay. To evaluate filter scavenging of C5a, an in vitro model was developed to generate high levels of C5a in plasma by activating plasma with zymosan. Levels of C3a, C5a, IL-8, and RANTES were reduced by filtration through two bedside platelet WBC-reductio...Continue Reading
Citations
Jan 30, 2004·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Kenneth Wong, Xuebin Li
Oct 16, 2002·Thrombosis Research·Margarethe Heiden, Rainer Seitz
Apr 5, 2002·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·J SeghatchianM Wadhwa
Dec 25, 2003·Transfusion·Justin C PaglinoEdward L Snyder
Oct 21, 1998·Vox Sanguinis·T ShimizuK Ozawa
Mar 24, 2000·Vox Sanguinis·C WillyW A Flegel
May 21, 1999·Transfusion·M FujiharaS Sekiguchi
Jul 21, 1999·Transfusion·D V DevineM I Gyongyossy-Issa
Apr 25, 2000·Transfusion·M P BuschW Heneine
Aug 5, 2000·Transfusion·F FerrerV Vicente
Nov 5, 1999·Current Opinion in Hematology·N M Heddle
Aug 15, 1998·Vox Sanguinis·T E Mollnes
Jun 24, 2003·Anesthesia and Analgesia·Boris NohéHans-Juergen Dieterich
Jul 27, 2001·British Journal of Haematology·R CardiganL M Williamson
May 11, 2001·American Journal of Clinical Pathology·J D Sweeney
Aug 3, 2004·Transfusion Medicine·M HeidenR Seitz
Oct 20, 2004·Journal of Clinical Apheresis·Thierry BurnoufThomas Burkhardt
Apr 26, 2007·Vox Sanguinis·C PolitisP Ziroyannis
Dec 17, 2008·Vox Sanguinis·R D Davenport
Jan 7, 2010·Transfusion·Shigenori TanakaFumiya Hirayama
Jan 13, 2015·Experimental and Therapeutic Medicine·Dai-Yu LiHua Zhao
Nov 1, 2016·Experimental Biology and Medicine·Hadi Abou-El-Hassan, Hassan Zaraket
May 4, 2001·Perfusion·M B PatelW W O'Neill
May 1, 2004·Journal of Infusion Nursing : the Official Publication of the Infusion Nurses Society·Girolamo A OrtolanoBarry Wenz