PMID: 6111754Apr 9, 1981Paper

Removal of bound calcium from nematocyst contents causes discharge

Nature
R Lubbock, W B Amos

Abstract

Nematocysts are the stinging organelles of jellyfish, sea anemones and other cnidarians. Each one consists of a closed capsule filled with fluid. In the resting state, part of the surface of the capsule is inverted, forming a tubular thread, which is everted explosively on excitation. The mechanism of explosion is not yet understood, it may be relevant to exocytosis in general, as the nematocyst is a specialized type of exocytotic secretion originating in the Golgi apparatus. Picken and Skaer observed that the capsular fluid showed a large depression of freezing point, suggesting that the osmotic pressure might be as high as 140 bar. They tentatively ascribed the explosion to a sudden increase in permeability of the capsule wall, allowing a rapid osmotic influx of water. However, there is evidence that the material of the thread itself may be capable of some degree of extension and it has been suggested that osmosis plays no part in discharge. We present here a new theory: that the capsule wall is permeable to water even in the undischarged state; discharge is initiated by an increase in the osmotic pressure of the capsular fluid which is brought about by removal of bound calcium ions.

Citations

May 1, 1986·Pflügers Archiv : European journal of physiology·O Skøtt
Mar 1, 1994·Comparative Biochemistry and Physiology. Comparative Physiology·G M Watson, D A Hessinger
Jan 1, 1985·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·M A Phelan, R S Blanquet
Jan 28, 2003·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Paul G GreenwoodCynthia Lohmann
Jun 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·R LubbockT A Hall
May 1, 1990·The Journal of protozoology·I Desportes-Livage, G Nicolas
Sep 30, 2009·Journal of Biological Engineering·Shawn C OppegardDavid T Eddington
Feb 26, 2013·Marine Drugs·Luca CegolonGiuseppe Mastrangelo
Aug 16, 2011·International Journal of Pharmaceutics·Ari AyalonTamar Lotan
Feb 2, 2010·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Laura M BirsaRichard F Lee
Nov 7, 2015·Toxicon : Official Journal of the International Society on Toxinology·Min-Jung PyoEuikyung Kim
Aug 5, 2008·Trends in Genetics : TIG·Charles N DavidThomas W Holstein
Aug 25, 2006·Toxicon : Official Journal of the International Society on Toxinology·James Tibballs
May 16, 2019·Proceedings of the National Academy of Sciences of the United States of America·S I HanT A Blackledge
May 27, 2020·ELife·Keiko WeirNicholas W Bellono
Feb 24, 1984·Science·T Holstein, P Tardent

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