Abstract
In patients with quiescent asthma, macrophages are the most prevalent cells recovered by bronchoalveolar lavage (BAL). Through activation via their FcepsilonRII receptors or by acting as antigen-presenting cells, macrophages could, in theory, promote the late airway response to allergen. In order to investigate the importance of macrophages and other airway luminal cells in inducing the late airway response, a novel washout experiment was designed. Five patients with ragweed-allergic asthma underwent bronchoscopy and segmental bronchial challenge with either normal saline or short ragweed extract in two segments of one lung. In a third segment of the opposite lung, 12 successive BALs (25 mL each) were performed, followed by challenge with an identical dose of short ragweed (washed-challenged segment). After 24 h, all three challenged segments underwent BAL. Initially, in the washed-challenged segment, over 80% (mean 80.4%, range 68-88%) of the recoverable airway dwelling cells were removed. Unexpectedly, 24 h later these same washed-challenged segments contained more eosinophils in the BAL than the challenged segments from the opposite lung (P = 0.033). Removing the majority of airway luminal cells followed by allergen bronchop...Continue Reading
References
Aug 1, 1979·Cellular Immunology·J P DessaintA Capron
May 1, 1992·The Journal of Allergy and Clinical Immunology·D H BroideS I Wasserman
Dec 1, 1992·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·T ThepenP G Holt
Aug 1, 1992·The Journal of Allergy and Clinical Immunology·N TeradaK Togawa
Sep 1, 1992·American Journal of Respiratory Cell and Molecular Biology·M J ThomassenH P Wiedemann
Apr 1, 1992·The Journal of Allergy and Clinical Immunology·R DupuisS P Peters
Oct 1, 1991·The Journal of Allergy and Clinical Immunology·D H BroideS I Wasserman
Dec 1, 1991·The American Review of Respiratory Disease·J B SedgwickW W Busse
Mar 1, 1991·The American Review of Respiratory Disease·A A GerblichM R Schuyler
Jan 1, 1988·The American Review of Respiratory Disease·A J WardlawA B Kay
Aug 1, 1989·The Journal of Experimental Medicine·T ThepenG Kraal
Jun 1, 1989·The American Review of Respiratory Disease·P DiazA B Kay
Sep 1, 1987·The American Review of Respiratory Disease·M C GonzalezA B Kay
May 1, 1988·Thorax·N Carroll, M A Branthwaite
May 1, 1988·Thorax·M L WilsherP L Haslam
Feb 1, 1983·The Journal of Clinical Investigation·M JosephJ Benveniste
Apr 1, 1995·American Journal of Respiratory and Critical Care Medicine·J C VirchowC Kroegel
Jan 1, 1995·European Journal of Immunology·B LamkhiouedM Capron
Jun 1, 1994·American Journal of Respiratory and Critical Care Medicine·L W HuntS Sur
Jun 1, 1996·American Journal of Respiratory and Critical Care Medicine·M HumbertA B Kay
Nov 1, 1995·Allergy·S SurL W Hunt
Aug 1, 1996·American Journal of Respiratory and Critical Care Medicine·L M TeranS T Holgate
May 1, 1959·A.M.A. Journal of Diseases of Children·M E AVERY, J MEAD
Citations
Feb 25, 2010·PloS One·Nilesh DharajiyaSanjiv A Sur
Apr 4, 2002·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·T T HanselP J Barnes
Jun 9, 2009·Molecular Immunology·Grzegorz ChodaczekIstvan Boldogh
Oct 8, 2003·Molecular Therapy : the Journal of the American Society of Gene Therapy·Michael EmersonD David S Collie