PMID: 11929484Apr 4, 2002Paper

Removal of bronchoalveolar cells augments the late eosinophilic response to segmental allergen challenge

Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
L W HuntSanjiv Sur

Abstract

In patients with quiescent asthma, macrophages are the most prevalent cells recovered by bronchoalveolar lavage (BAL). Through activation via their FcepsilonRII receptors or by acting as antigen-presenting cells, macrophages could, in theory, promote the late airway response to allergen. In order to investigate the importance of macrophages and other airway luminal cells in inducing the late airway response, a novel washout experiment was designed. Five patients with ragweed-allergic asthma underwent bronchoscopy and segmental bronchial challenge with either normal saline or short ragweed extract in two segments of one lung. In a third segment of the opposite lung, 12 successive BALs (25 mL each) were performed, followed by challenge with an identical dose of short ragweed (washed-challenged segment). After 24 h, all three challenged segments underwent BAL. Initially, in the washed-challenged segment, over 80% (mean 80.4%, range 68-88%) of the recoverable airway dwelling cells were removed. Unexpectedly, 24 h later these same washed-challenged segments contained more eosinophils in the BAL than the challenged segments from the opposite lung (P = 0.033). Removing the majority of airway luminal cells followed by allergen bronchop...Continue Reading

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Citations

Apr 4, 2002·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·T T HanselP J Barnes
Oct 8, 2003·Molecular Therapy : the Journal of the American Society of Gene Therapy·Michael EmersonD David S Collie

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