Removal of cartilage rings prevents graft stenosis in extended tracheal allotransplantation with omentopexy and immunosuppression: an experimental study

The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation
Toshiaki MasaokaYasuhisa Shimazaki

Abstract

One of the serious problems in longer size tracheal transplantation is severe stenosis of the graft, probably caused by an inadequate blood supply. We have previously reported that removal of some cartilage rings of the graft and omentopexy helps to provide sufficient blood flow to the graft mucosal tissue and results in satisfactory survival and non-significant graft stenosis in extended tracheal autotransplantation. However, it is unclear whether this method can be applied to extended tracheal allotransplantation that requires immunosuppression. In this report, we describe midterm results of extended tracheal allotransplantation with the technique. Twenty-four adult mongrel dogs were used. In 18 dogs, a nine-cartilage-ring length of the trachea was allotransplanted when five cartilage rings of the graft were removed, leaving two rings intact at both ends of the graft for simple fixing to the recipient. Two artificial tracheal rings outside the graft and a stent inside the graft were used for maintaining the lumen width. Omentopexy was done for sufficient blood supply to the graft. FK 506 (0.1 mg/kg) was given on each day after the operation in Group A (n = 10), but was not given at all in Group B (n = 8). In Group C (n = 6), ...Continue Reading

References

Apr 1, 1994·The Annals of Thoracic Surgery·R NakanishiT Takachi
May 1, 1995·The Journal of Thoracic and Cardiovascular Surgery·R NakanishiT Shirakusa
Apr 24, 1999·The Annals of Thoracic Surgery·K MuraiY Shimazaki

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Citations

Jun 25, 2002·The Annals of Thoracic Surgery·Hermes C Grillo
Aug 6, 1998·The Annals of Thoracic Surgery·T MukaidaS Moriyama
Mar 17, 2009·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Xiaofei LiKun Liu

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