PMID: 9192234Jun 1, 1997Paper

Removal of endogenous leptin from the circulation by the kidney

International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity
F CuminN Levens

Abstract

This study was performed to test the hypothesis that the kidneys play a primary role in the clearance of endogenous leptin from the circulation of obese rats. Zucker (fa/fa) obese rats were anaesthetized and subjected to various surgical manipulations of the kidneys. One hour after surgery arterial blood samples were taken at 1 h intervals for times upto 8 h. Plasma leptin concentrations were determined by radioimmunoassay. Bilateral nephrectomy induced a rapid increase in plasma leptin concentrations above control values. In contrast, continuous intravenous re-injection of voided urine did not increase circulating leptin concentrations, indicating that leptin is not present in the urine in large quantities. This conclusion was confirmed by the very low levels of detectable leptin in urine. Leptin is not metabolized across the renal circulation and is extracted intact by the kidney. Simultaneous measurement of renal plasma flow established renal leptin extraction at approximately 59 ng/ min for both kidneys. Following intravenous infusion of leptin, renal clearance and whole body clearance were equal. This finding indicates that the kidneys alone are responsible for the systemic elimination of leptin in Zucker rats. Seven hours...Continue Reading

Citations

Jan 5, 2011·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Wai W CheungRobert H Mak
Dec 12, 2012·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Sujana S Gunta, Robert H Mak
Oct 24, 1998·Clinical Physiology·G FrühbeckA M Prentice
Oct 10, 1998·Kidney International·L NordforsP Stenvinkel
Jun 2, 1998·Kidney International·K Sharma, R V Considine
Apr 29, 1997·Proceedings of the National Academy of Sciences of the United States of America·J S Flier
Jan 22, 2011·International Journal of Hypertension·Shilpa KshatriyaDaniel Villarreal
Jul 30, 2014·The Journal of Pediatrics·Edward NehusMark Mitsnefes
Feb 22, 2013·The American Journal of the Medical Sciences·Orson GoDaniel Villarreal
Feb 5, 2013·Seminars in Nephrology·Marcin Adamczak, Andrzej Wiecek
May 29, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J H HenriksenF Bendtsen
Oct 13, 2012·The Journal of Surgical Research·Karen J HoCharles Keith Ozaki
Mar 7, 2006·Kidney International·R H MakD L Marks
May 1, 2010·Transplantation Proceedings·M TaherimahmoudiG Pourmand
Sep 3, 2009·Molecular and Cellular Endocrinology·Sandra GalicGregory R Steinberg
Nov 16, 1999·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Y TsujimotoH Morii
Apr 14, 2012·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·P M M Moraes-VieiraN O S Câmara
Oct 28, 2014·Clinical and Experimental Immunology·Jack HutchesonTianfu Wu
Oct 27, 1999·Metabolism: Clinical and Experimental·B Fruehwald-SchultesA Peters
May 5, 2004·The Urologic Clinics of North America·Jack H Mydlo
Dec 3, 2014·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Jau-Yuan ChenWen-Cheng Li
Jul 5, 2013·PloS One·Dafne Pérez-MontareloAna I Fernández
Nov 16, 1999·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·M P FontánJ García-Buela
Dec 16, 2016·International Journal of Molecular Sciences·Salvatore PettaFerruccio Bonino
May 23, 1998·The Journal of Biological Chemistry·C LiJ M Friedman
Feb 2, 2018·Journal of Receptor and Signal Transduction Research·Song MaoJianhua Zhang
Dec 29, 2000·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·B AhrénP J Havel
Oct 24, 2009·Current Opinion in Nephrology and Hypertension·Shilpa KshatriyaDaniel Villarreal
Dec 26, 2001·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·A B JenkinsL V Campbell
Apr 11, 2007·Digestive Diseases and Sciences·G Joel ReynoldsWillem J S de Villiers
Apr 4, 2001·Obstetrical & Gynecological Survey·J C Sabogal, L Muñoz
Jul 15, 1999·The Journal of Clinical Endocrinology and Metabolism·S Reichlin
Jan 30, 1999·The American Journal of Clinical Nutrition·M D JensenS Klein
Dec 13, 2005·The Biochemical Journal·Gema Frühbeck
Nov 14, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·A M MadieheD A York
Oct 2, 1998·The American Journal of Physiology·M A PelleymounterM McCaleb
Sep 2, 1998·The American Journal of Physiology·M LandtB W Patterson
Jul 7, 2001·American Journal of Physiology. Endocrinology and Metabolism·A J FogtelooP W De Leeuw
Jul 8, 2018·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Nur CanpolatSalim Caliskan
May 1, 2021·International Journal of Molecular Sciences·Justyna KorczynskaTomasz Sledzinski
Dec 4, 2019·Aging and Disease·Dae Hyun KimHae Young Chung

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