Removal of Fe3+ and Zn2+ from plasma metalloproteins by iron chelating therapeutics depicted with SEC-ICP-AES

Dalton Transactions : an International Journal of Inorganic Chemistry
Melani Sooriyaarachchi, Jürgen Gailer

Abstract

The iron chelation therapy drugs desferrioxamine B (DFO) and deferiprone (DFP) are used to treat iron overload patients, but not much is known about their adverse effects on other essential metals in vivo. After the addition of a clinically relevant dose of DFP or an equimolar dose of DFO to human plasma in vitro, the mixtures were analyzed by size exclusion chromatography (SEC) coupled to an inductively coupled plasma atomic emission spectrometer (ICP-AES). Simultaneous detection of the emission lines of copper, iron and zinc allowed the visualization of changes that these drugs exerted at the metalloprotein level. After the addition of DFP, a <10 kDa novel Fe-peak was detected and identified as (DFP)(3)Fe, whereas DFO resulted in the elution of a much smaller amount of Fe in this elution range. In fact, DFP was approximately 8-times more efficient than DFO regarding the removal of Fe from plasma proteins. The addition of both iron chelators also resulted in the elution of a <10 kDa novel Zn-peak. DFP abstracted twice as much Zn from plasma proteins compared to DFO. The identification of one of these peaks as (DFP)(2)Zn establishes a feasible biomolecular basis for the etiology of Zn-deficiency in patients that undergo long-te...Continue Reading

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Citations

Apr 17, 2013·Blood Cells, Molecules & Diseases·Naji S MallatAli T Taher
Jan 25, 2014·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Melani SooriyaarachchiJürgen Gailer
Jul 24, 2012·Metallomics : Integrated Biometal Science·Elham Zeini Jahromi, Jürgen Gailer
Feb 28, 2013·Metallomics : Integrated Biometal Science·Melani SooriyaarachchiJürgen Gailer
Oct 29, 2013·Survey of Ophthalmology·Marta UgartePaul N Bishop
Apr 1, 2016·Expert Opinion on Drug Delivery·Abhishek Yadav, Swaran Jeet Singh Flora
Jan 30, 2015·The Journal of Pharmacy and Pharmacology·Kanjana PangjitSomdet Srichairatanakool
Sep 13, 2014·Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan·Yusuke IwasakiKoichi Saito
Oct 16, 2019·Metallomics : Integrated Biometal Science·James P C CoverdaleClaudia A Blindauer
Dec 8, 2010·Metallomics : Integrated Biometal Science·Melani SooriyaarachchiJürgen Gailer
Sep 13, 2019·Journal of Inorganic Biochemistry·Sophia Sarpong-Kumankomah, Jürgen Gailer
Jun 29, 2011·Journal of Inorganic Biochemistry·Marina G D LeedKatherine J Franz

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