PMID: 9655609Jul 9, 1998Paper

Removal of GABAergic inhibition in the mediodorsal nucleus of the rat thalamus leads to increases in heart rate and blood pressure

Neuroscience Letters
E Stotz-Potter, E Benarroch

Abstract

The mediodorsal nucleus of the thalamus (MD) has connections with central autonomic centers involved in cardiovascular control and undergoes severe degeneration in fatal familial insomnia, a human disease characterized by progressive dysautonomia. Microinjections of the GABAA antagonist bicuculline methiodide (BMI) into the medial and central portion of the MD lead to significant, dose-dependent increases in both heart rate and blood pressure. Similar injections into surrounding regions elicited little to no change. The data suggest that the medial and central portion of the MD plays a role in central cardiovascular regulation. Neurons of the MD may be under tonic GABAergic inhibition, and disruption of circuits at this level may underlie dysautonomia in many neurological diseases.

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Citations

Feb 15, 2001·Current Hypertension Reports·J H MarkovitzK Davidson
Apr 17, 2002·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·P Montagna, E Lugaresi
May 7, 2010·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·A Raggi, R Ferri
May 10, 2002·Circulation Journal : Official Journal of the Japanese Circulation Society·Seiji YoshidaNigishi Hotta
Jul 10, 2003·Lancet Neurology·Pasquale MontagnaElio Lugaresi
Jan 13, 2016·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Serge Mrkobrada
Oct 16, 2015·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Serge MrkobradaVithya Gnanakumar
Aug 20, 2005·Sleep Medicine Reviews·Pasquale Montagna
Mar 20, 2019·Experimental Brain Research·Marco LuppiRoberto Amici
Jun 10, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·G J Kirouac, Q J Pittman
May 17, 2012·Physiological Genomics·Elaine M SmolockVyacheslav A Korshunov

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