PMID: 6105247Jul 12, 1980Paper

Removal of hepatitis-B-virus infectivity from factor-IX complex by hepatitis-B immune-globulin. Experiments in chimpanzees

Lancet
E TaborR J Gerety

Abstract

Hepatitis-B-virus infectivity can be removed from a heat-labile clotting factor concentrate by the addition of hepatitis-B immune-globulin. Three chimpanzees were each inoculated with samples of factor-IX complex (factor IX) which had been deliberately contaminated with 10(3.5) chimpanzee infectious doses of hepatitis-B virus from a known infectious inoculum. Two of these factor IX samples had been incubated with hepatitis-B immune-globulin after the addition of hepatitis-B virus. 10 weeks after inoculation hepatitis-B infection developed in the chimpanzee inoculated with untreated factor IX. Hepatitis B did not develop in the two which received treated factor IX; no serloigical evidence of hepatitis B could be detected during 52 weeks of evaluation.

References

Jun 1, 1973·The Journal of Infectious Diseases·L F BarkerM R Peterson
Jan 1, 1955·Journal of the American Medical Association·R MURRAYH GELLER

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Citations

Jul 1, 1985·Journal of Virological Methods·M GovenderJ D Conradie
Oct 28, 1998·Vox Sanguinis·H RollagJ L Svennevig
Aug 1, 1988·British Journal of Haematology·J EiblK Anderle
Dec 18, 2001·Biomedical Chromatography : BMC·R Cameron-Smith, C Harbour
Nov 1, 1985·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R H PurcellM E Hrinda
Nov 1, 1981·Vox Sanguinis·S Chandra, H G Brummelhuis
May 10, 2006·Journal of Thrombosis and Thrombolysis·Antonio GirolamiBruno Girolami
Jan 1, 1984·Scandinavian Journal of Haematology. Supplementum·R Gerety

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