Removal of malaria-infected red blood cells using magnetic cell separators: A computational study.

Applied Mathematics and Computation
Jeongho KimAlberto Gandini

Abstract

High gradient magnetic field separators have been widely used in a variety of biological applications. Recently, the use of magnetic separators to remove malaria-infected red blood cells (pRBCs) from blood circulation in patients with severe malaria has been proposed in a dialysis-like treatment. The capture efficiency of this process depends on many interrelated design variables and constraints such as magnetic pole array pitch, chamber height, and flow rate. In this paper, we model the malaria-infected RBCs (pRBCs) as paramagnetic particles suspended in a Newtonian fluid. Trajectories of the infected cells are numerically calculated inside a micro-channel exposed to a periodic magnetic field gradient. First-order stiff ordinary differential equations (ODEs) governing the trajectory of particles under periodic magnetic fields due to an array of wires are solved numerically using the 1(st) -5(th) order adaptive step Runge-Kutta solver. The numerical experiments show that in order to achieve a capture efficiency of 99% for the pRBCs it is required to have a longer length than 80 mm; this implies that in principle, using optimization techniques the length could be adjusted, i.e., shortened to achieve 99% capture efficiency of the...Continue Reading

References

Jan 1, 1984·Pathology·R K Kumar, A W Lykke
Mar 14, 2000·The Journal of Infection·N J White
Apr 2, 2003·Biophysical Journal·Maciej ZborowskiAlan N Schechter
Apr 19, 2003·Transfusion·Fouad BoctorJoan Uehlinger
Aug 22, 2003·Critical Care : the Official Journal of the Critical Care Forum·Andrej TrampuzRajesh M Prabhu
Jan 28, 2004·Acta Tropica·Peter GascoyneMathuros Ruchirawat
Jul 12, 2005·Annual Review of Biomedical Engineering·Mehmet Toner, Daniel Irimia
Oct 20, 2005·Lab on a Chip·Christian Mikkelsen, Henrik Bruus
Dec 24, 2005·Lab on a Chip·Nicole Pamme
Feb 8, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Lee R MooreMaciej Zborowski
Sep 5, 2006·IEE Proceedings. Nanobiotechnology·K-H Han, A B Frazier
Sep 28, 2006·Biomedical Microdevices·Nan XiaDonald E Ingber
Aug 19, 2007·American Journal of Hematology·Fouad N Boctor, R Patrick Dorion
Dec 6, 2008·Biochimica Et Biophysica Acta·S HackettT G St Pierre
Feb 4, 2010·Malaria Journal·Sebastian C BhakdiHartmut P H Neumann

❮ Previous
Next ❯

Citations

May 3, 2014·International Journal of Engineering Science·Wei-Tao WuJames F Antaki
Oct 21, 2016·Microfluidics and Nanofluidics·Wei-Tao WuJames F Antaki
Sep 19, 2015·Parasites & Vectors·Alexandra G PershinaLudmila M Ogorodova
Feb 22, 2014·Biochimica Et Biophysica Acta·Lorena M CoronadoCarmenza Spadafora
Dec 5, 2014·Reports on Progress in Physics·Brian D PlouffeLaura H Lewis
Sep 11, 2019·Physical Review. E·Spencer H BryngelsonJonathan B Freund
Aug 20, 2019·Proceedings. Mathematical, Physical, and Engineering Sciences·Bhargav RallabandiHoward A Stone
May 23, 2020·Acta Biomaterialia·Kaitlyn BaconStefano Menegatti
Dec 5, 2018·Chemical Reviews·Christine F MarkwalterDavid W Wright

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

© 2022 Meta ULC. All rights reserved