Removal of morphine with the new high-efficiency and high-flux membranes during haemofiltration and haemodialfiltration

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
J A JamalB Bastani

Abstract

We present three critically ill patients with severe renal failure who required haemofiltration or haemodiafiltration, with high-efficiency or high-flux membranes, while receiving an intravenous infusion of morphine. We show that despite the very high ultrafiltrability/diffusability of free morphine, only 1-3% of the total amount of infused morphine is removed in 24 h. This is in marked contrast to haemodialysis where, owing to much higher dialysate flow rate, a significant quantity of free morphine is removed.

Citations

Apr 17, 2015·Seminars in Dialysis·Ameet KarambelkarPaul M Palevsky
Jun 19, 2004·The International Journal of Artificial Organs·A BrendolanG Salvadori
Feb 7, 2004·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Olivier Joannes-BoyauGerard Janvier
Apr 3, 2012·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Fumi SuzukiHiroyasu Ogata
Sep 13, 2017·The American Journal of Emergency Medicine·Brit LongCourtney M Lee
Aug 6, 2003·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Manjula KurellaGlenn M Chertow
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Jan 6, 2012·British Journal of Anaesthesia·N ArulkumaranM Singer

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