PMID: 9179596Jun 1, 1997Paper

Removal of retrogradely transported material from rat lumbosacral alpha-motor axons by paranodal axon-Schwann cell networks

Glia
Kliment P GatzinskyClaes-Henric Berthold

Abstract

The aim of this study was to investigate the potential ability of Schwann cells to sequester axonally transported material via so called axon-Schwann cell networks (ASNs). These are entities consisting of sheets of Schwann cell adaxonal plasma membrane that invade the axon and segregate portions of axoplasm in paranodes of large myelinated mammalian nerve fibres. Rat hindlimb alpha-motor axons were examined in the L4-S1 ventral roots using light/fluorescence, confocal laser, and electron microscopy for detection of retrogradely transported red-fluorescent latex nanospheres taken up at a sciatic nerve crush, and intramuscularly injected horseradish peroxidase endocytosed by intact synaptic terminals. Survival times after tracer administration ranged from 27 hours to 4 weeks. During their retrograde transport toward the motor neuron perikarya, organelles carrying nanospheres/peroxidase accumulated at nodes of Ranvier, where they often appeared in close association with the paranodal myelin sheath. Serial section electron microscopy showed that many of the tracer-containing bodies were situated within ASN complexes, thereby being segregated from the main axon. Four weeks after nanosphere administration, several node-paranode regio...Continue Reading

References

Oct 1, 1992·Journal of Neuroscience Methods·G BalerciaM Bentivoglio
May 31, 1990·Neuroscience Letters·M Bentivoglio, H S Su
Jan 1, 1991·Annals of the New York Academy of Sciences·R M Grossfeld
Jun 1, 1991·Journal of Neurocytology·A Reles, R L Friede
Apr 30, 1990·Biochimica Et Biophysica Acta·H M FishmanP G Stein
Jan 1, 1988·Glia·R M GrossfeldL C Stewart
Jun 1, 1985·Journal of Neurochemistry·T D LindquistN A Ingoglia
May 1, 1988·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·J H Sandell, R H Masland
Apr 1, 1988·Journal of Neuroscience Methods·R Egensperger, H Holländer
Jun 18, 1971·Brain Research·K Kristensson, Y Olsson
Apr 1, 1966·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·R C Graham, M J Karnovsky
Dec 1, 1982·Journal of Neurochemistry·R M GouldN A Ingoglia
Jan 1, 1980·Acta Neuropathologica·P K ThomasA K Sharma
Mar 1, 1981·Journal of Neuropathology and Experimental Neurology·N Grover-Johnson, P S Spencer
May 1, 1993·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·L C Schmued, L F Snavely
Apr 11, 1995·Proceedings of the National Academy of Sciences of the United States of America·C C OverlyP J Hollenbeck
Oct 1, 1994·Current Opinion in Neurobiology·D L Coy, J Howard
Nov 1, 1994·Progress in Neurobiology·E M LiebermanR M Grossfeld
Jan 1, 1994·Journal of Neuroscience Research·L M Bolin, E M Shooter
Nov 1, 1995·Trends in Neurosciences·R A Nixon, A M Cataldo
Aug 15, 1996·Microscopy Research and Technique·K P Gatzinsky

❮ Previous
Next ❯

Citations

Mar 27, 2001·Muscle & Nerve·R Martini
Jul 20, 2006·International Anesthesiology Clinics·Elizabeth Vernon PittsRita J Balice-Gordon
Dec 27, 2007·PloS One·Jean-Pierre RoussarieMichel Brahic
Sep 26, 2009·PLoS Pathogens·Michel Brahic, Jean-Pierre Roussarie
Jun 15, 2007·The European Journal of Neuroscience·Samantha BowenJoanne E Martin
May 9, 2006·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Z CaiP D Thompson
Oct 15, 2003·Neuron·James L Salzer
Jun 19, 2004·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Karsten VeldeRichard R Miselis
Jan 24, 2007·Acta Neuropathologica·Andrew P MizisinG Diane Shelton

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.