Removal of xenotropic murine leukemia virus by nanocellulose based filter paper

Biologicals : Journal of the International Association of Biological Standardization
M AsperAlbert Mihranyan

Abstract

The removal of xenotrpic murine leukemia virus (xMuLV) by size-exclusion filter paper composed of 100% naturally derived cellulose was validated. The filter paper was produced using cellulose nanofibers derived from Cladophora sp. algae. The filter paper was characterized using atomic force microscopy, scanning electron microscopy, helium pycnometry, and model tracer (100 nm latex beads and 50 nm gold nanoparticles) retention tests. Following the filtration of xMuLV spiked solutions, LRV ≥5.25 log10 TCID50 was observed, as limited by the virus titre in the feed solution and sensitivity of the tissue infectivity test. The results of the validation study suggest that the nanocellulose filter paper is useful for removal of endogenous rodent retroviruses and retrovirus-like particles during the production of recombinant proteins.

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Citations

Mar 25, 2016·Colloids and Surfaces. B, Biointerfaces·Changgang XuAlbert Mihranyan
May 5, 2016·ACS Applied Materials & Interfaces·Simon Gustafsson, Albert Mihranyan
Mar 10, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Igor RochaNatalia Ferraz
Mar 8, 2018·MAbs·Alexandre AmbrogellyHongcheng Liu
May 1, 2019·Preparative Biochemistry & Biotechnology·Roya KhosraviSeyed Dawood Mousavi Nasab
Jul 11, 2018·Global Challenges·Olof GustafssonAlbert Mihranyan
Jan 1, 2017·Re/views in Environmental Science and Bio/technology·Guy-Alain Junter, Laurent Lebrun
Jul 19, 2018·Biomacromolecules·Ragab E AbouzeidAlain Dufresne
Apr 27, 2017·Langmuir : the ACS Journal of Surfaces and Colloids·Simon GustafssonAlbert Mihranyan
Jan 1, 2021·ACS Applied Bio Materials·Levon ManukyanAlbert Mihranyan

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