PMID: 8586997Oct 1, 1995Paper

Remyelination of mouse spinal cord axons demyelinated by local injection of lysolecithin

Journal of Neurocytology
N D Jeffery, W F Blakemore

Abstract

Local injections of lysolecithin are commonly used to produce areas of demyelination in the CNS. For the mouse, the demyelinating initial phase of lesion development has been described previously but the spontaneous repair which follows has not. In this study we describe the morphological sequelae which result from the injection of 2 microliters of 1% lysolecithin into the spinal cord of adult mice. Lesion length was variable, extending 8 mm or more in 33% of lesioned animals. By 7 days after injection very little extracellular myelin debris was detected and remyelination had commenced. Remyelination progressed rapidly so that almost all axons were invested by myelin sheaths by 23 days. Remyelination was accompanied by a prominent astrocytosis. The long lesion length and the rapidity of repair has important implications for studies designed to assess the ability of transplanted myelinogenic cells to migrate towards demyelinating lesions.

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Citations

Dec 11, 2003·Molecular and Cellular Neurosciences·Susna DeSamuel David
Jan 1, 1997·Journal of Anatomy·R J Franklin, W F Blakemore
Nov 1, 2007·Journal of Neurotrauma·Monica M SiegenthalerHans S Keirstead
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Jul 7, 2011·Journal of Neuroinflammation·Samuel J JacksonDavid Baker
Apr 11, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jurate LasienePhilip Horner
Jul 24, 2012·Regenerative Medicine·Alberto HayekThomas Bollenbach
Mar 4, 2014·Progress in Neurobiology·Jason R PlemelWolfram Tetzlaff
Nov 22, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sharyl L Fyffe-MaricichRobert H Miller
Aug 8, 2012·Biochimica Et Biophysica Acta·Ioanna SevastouVassilis Aidinis
Jun 12, 2010·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Aleksandar DenicIstvan Pirko
Jul 18, 2009·Journal of the Neurological Sciences·Christopher Gregg
Oct 4, 2005·Brain Pathology·François LachapelleAnne Baron-Van Evercooren
Apr 1, 2015·European Journal of Pharmacology·Claudio ProcacciniGiuseppe Matarese
Dec 13, 2006·The European Journal of Neuroscience·K B MarquesA L R Oliveira
Feb 25, 2006·Annals of Neurology·Nai-Kui LiuXiao-Ming Xu
May 23, 2014·Genesis : the Journal of Genetics and Development·Yaqi DengQ Richard Lu
Apr 14, 2016·Experimental Neurology·Ian D Duncan, Abigail B Radcliff
Sep 1, 2015·Frontiers in Neurology·Abdullah Shafique AhmadSylvain Doré
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Feb 15, 2002·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Samuel David, Shalina S Ousman

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