Renal ablation by histotripsy--does it spare the collecting system?

The Journal of Urology
Alison M LakeWilliam W Roberts

Abstract

The feasibility of histotripsy (transcutaneous nonthermal mechanical tissue fractionation) was previously demonstrated in an in vivo rabbit renal cortex model. We explored the spectrum of histotripsy bio-effects on different tissue types in an in vitro porcine kidney model. Using an 18 element focused annular array ultrasound system we performed histotripsy treatments in 5 in vitro porcine kidneys, targeting 7 cortical volumes and 17 tissue volumes bridging the cortex, medulla and/or collecting system. Treated areas were observed using ultrasound. In 5 lesions methylene blue was infused into the collecting system to evaluate the preservation of collecting system integrity. Kidneys were sectioned and examined grossly for evidence of tissue fractionation, ie the presence of histotripsy paste, or fixed in formalin and prepared for histological analysis. Histotripsy of renal cortical tissue created tissue defects in the cortical area treated. Histotripsy targeting the renal collecting system, medulla and renal cortex resulted in tissue fractionation in the area of the cortex, intermediate damage in the medulla and minimal damage to the collecting system. There is a differential histotripsy treatment effect when comparing renal cort...Continue Reading

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Citations

Jun 26, 2010·Journal of Endourology·Nicholas R StynWilliam W Roberts
Nov 26, 2010·Journal of Endourology·Alexander P DuryeaWilliam W Roberts
Dec 1, 2010·Indian Journal of Urology : IJU : Journal of the Urological Society of India·Branden G Duffey, J Kyle Anderson
Jul 31, 2012·Urology·George R SchadeWilliam W Roberts
Dec 15, 2010·Ultrasound in Medicine & Biology·Frank WinterrothCharles A Cain
Sep 1, 2015·Ultrasound in Medicine & Biology·Eli VlaisavljevichCharles Cain
Jan 30, 2014·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·Eli VlaisavljevichZhen Xu
Sep 16, 2009·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·Tzu-yin WangCharles A Cain
Jan 24, 2015·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Emad S Ebbini, Gail ter Haar
Feb 25, 2015·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Vera A KhokhlovaCharles A Cain
Mar 31, 2015·Ultrasound in Medicine & Biology·Martijn HoogenboomGosse J Adema
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Jun 18, 2021·Frontiers in Oncology·Alissa Hendricks-WengerIrving Coy Allen
Jul 11, 2021·Cardiovascular and Interventional Radiology·Emily A KnottTimothy J Ziemlewicz
Sep 1, 2021·Ultrasound in Medicine & Biology·Lauren ArnoldEli Vlaisavljevich

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