Renal accumulation and excretion of radioiodinated 3-iodo-alpha-methyl-L-tyrosine

Annals of Nuclear Medicine
N ShikanoHideo Saji

Abstract

We investigated mechanisms of renal accumulation of radioiodinated 3-iodo-alpha-methyl-L-tyrosine (IMT), which has been used clinically for tumor imaging and as an amino acid transport marker in studies of brain and pancreas function. In this study, we used 125I- or 123I-labeled IMT ([125I]IMT or [123I]IMT) as the transport marker. Partition coefficients of [125I]IMT were determined for hypothetic urine at pH ranging from 5 to 8. The examination of uptake and inhibition of [125I]IMT was performed using normal human renal proximal tubule epithelial cells (RPTEC), which are characteristic of the proximal convoluted tubule. The plasma protein binding ratio of [125I]IMT was determined using rats. In the in vivo experiments using mice, we examined biodistribution and excretion inhibition, and performed whole body autoradiography. Also, renal SPECT using [123I]IMT was performed using a normal canine. Very low lipophilicity of [125I]IMT in hypothetic urine suggests that a carrier-mediated pathway contributes to its marked kidney accumulation. [125I]IMT uptake into RPTEC was significantly inhibited by 2-aminobicyclo[2,2,1]heptane-2-carboxylic acid (BCH) in a sodium-dependent manner, suggesting reabsorption mainly via system B0 in apica...Continue Reading

References

Jul 25, 1997·The Journal of Biological Chemistry·T SekineH Endou
Jan 5, 2000·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·L G FloresA Kubodera
Sep 18, 2002·Nuclear Medicine and Biology·Karl-Josef LangenHeinz H Coenen

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Citations

Apr 8, 2011·Nihon Hoshasen Gijutsu Gakkai zasshi·Keiichi Kawai
May 25, 2010·Nuclear Medicine Communications·Fan-Lin KongDavid J Yang
Sep 29, 2020·The Journal of Pharmacology and Experimental Therapeutics·Chunhuan JinYoshikatsu Kanai
Jun 30, 2012·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Pattama WiriyasermkulYoshikatsu Kanai

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