Renal acidification in patients with mineralocorticoid deficiency

G O PerezC A Vaamonde


Renal acidification was studied in eight patients with Addison's disease or bilateral adrenalectomy receiving glucocorticoid replacement only and without renal insufficiency (group I); in five patients with hyporeninemic hypoaldosteronism and moderate chronic renal insufficiency (group II), and in nine control subjects (group III). During acidosis minimal urine pH was 5.4 or less in all subjects, but excretion of ammonium and titratable acid was moderately reduced in group I and markedly reduced in group II. Bicarbonate excretion at normal serum bicarbonate concentration was trivial in group I subjects and inappropriately elevated in two group II patients.


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Sep 7, 1978·The New England Journal of Medicine·M CoxI Singer
Apr 1, 1981·Kidney International·A H DubrovskyD Z Levine
Jul 1, 1984·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·J Kiley, P Zager
Apr 1, 1984·Kidney International·C Kornandakieti, R L Tannen
Jan 1, 1980·Kidney International·R A DeFronzo

Related Concepts

Anion Gap
Metabolic Acidosis
Addison Disease
Aldosterone, (+-)-Isomer
Carbonic Acid Ions
Clinical Trials
Glucocorticoid Effect

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Addison Disease

Addison's disease, also known as primary adrenal insufficiency and hypocortisolism, is a long-term endocrine disorder in which the adrenal glands do not produce enough steroid hormones. Discover the latest research on Addison's disease here.