PMID: 2206227Jul 1, 1990Paper

Renal allograft immunosuppression. I. Early inflammatory and rejection episodes in triple drug treatment compared to double drug combinations or cyclosporin monotherapy

Transplant International : Official Journal of the European Society for Organ Transplantation
H M IsoniemiP J Häyry

Abstract

We have investigated the impact of triple drug immunosuppression on the occurrence of early inflammatory episodes, as detected by fine needle aspiration biopsy, and of episodes of clinical rejection during the immediate postoperative period. The prospective component of this study includes 128 consecutive first cadaveric renal transplant recipients receiving triple drug treatment consisting of azathioprine (Aza), cyclosporin (CyA) and methylprednisolone (MP). For controls we have used three historical groups: one immunosuppressed with Aza and MP (group A), another with CyA monotherapy (group B), and the third with CyA together with MP (group C) in equivalent drug dosages. On the average, 0.8 episodes of inflammation per patient were recorded during the immediate postoperative period of 30 days with triple drug treatment. This was significantly less than the 1.3 episodes in patients receiving Aza and MP (P less than 0.01), the 1.7 episodes in patients on CyA monotherapy (P less than 0.001), or the 1.6 episodes in patients receiving CyA together with MP (P less than 0.001). Although the first episode of inflammation commenced concurrently in each group and the peak intensity of inflammation was the same, the mean duration of infl...Continue Reading

References

Mar 6, 1982·Lancet·P J MorrisA Ting
Oct 6, 1983·The New England Journal of Medicine·Canadian Multicentre Transplant Study Group
Apr 1, 1980·Transplantation·M G McGeownC M Hill

Citations

Apr 1, 1991·Transplant International : Official Journal of the European Society for Organ Transplantation·H M Isoniemi
Apr 1, 1996·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·J LaineP J Häyry
Aug 15, 2009·Magyar sebészet·Péter Szakály
Apr 29, 2014·Chemical Biology & Drug Design·Ashok K Kulkarni, Rajendra P Ojha
Jun 22, 2000·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·I MatlS Vítko

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