Renal allograft surveillance with allospecific T-cytotoxic memory cells.

Renal Failure
Vinayak S RohanSatish N Nadig

Abstract

Allo-antigen-specific T-cytotoxic memory cells (TcM) which express CD40 ligand (CD154) in overnight lymphocyte co-culture are strongly associated with acute cellular rejection (ACR) seen in "for cause" biopsies for renal allograft dysfunction. Specifically, when the likelihood of rejection is increased, donor-specific allospecific TcM exceed those induced by HLA-non-identical third-party cell by 1.15-fold or greater. The performance of allospecific TcM was evaluated retrospectively in primary renal transplant recipients (RTR) at routine clinical visits, cross-sectionally at presentation for biopsies, and serially. Performance metrics were sensitivity, specificity, positive and negative predictive values (PPV and NPV). Twenty-two primary RTR, median age 45 years (range 19-72) were tested with allospecific CD154 + TcM. Samples were obtained at the mean ± SD time interval of 806 ± 239 days after kidney transplantation. Six of 22 patients experienced biopsy proven T- Cell Mediated Rejection (TCMR). A seventh showed antibody mediated rejection (ABMR). Of these seven patients six demonstrated increased likelihood of rejection with allospecific TcM (sensitivity 83%). Ten of these 15 patients with no rejection had a negative test (spec...Continue Reading

References

Nov 4, 2008·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·C AshokkumarR Sindhi
May 22, 2010·Current Opinion in Organ Transplantation·Rakesh SindhiAdriana Zeevi
Oct 1, 2010·Transplantation·Chethan AshokkumarRakesh Sindhi
Mar 8, 2016·Transplantation·Chethan AshokkumarRakesh Sindhi
Dec 29, 2016·Journal of Hepatology·Kyle A SoltysIra J Fox
Nov 13, 2019·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Alberto Sánchez-FueyoGiovanna Lombardi

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Citations

Jun 8, 2021·Frontiers in Immunology·Xingqiang LaiZheng Jenny Zhang

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Methods Mentioned

BETA
biopsies
biopsy
flow cytometry

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