Renal amyloidosis in Whipple disease: a case report.

Cases Journal
Stanislaw NiemczykJoanna Matuszkiewicz Rowinska

Abstract

Whipple disease is a rare systemic infection caused by Tropheryma whippelii that usually manifests with joint pain, weight loss, diarrhoea and abdominal pain. However, in some cases the infection may involve other organs and tissues. We report on a 44-year-old man with Whipple disease which led to renal amyloidosis and end-stage renal failure. In this case, the patient was diagnosed with Whipple disease and commenced on a 12-month trimetoprime-sulfametoxasole therapy with good result. Six months after cessation of therapy the patient was readmitted to hospital due to signs of renal failure. An urgent kidney biopsy was performed which revealed secondary amyloidosis. Despite intensive immunosuppressive treatment, renal parameters gradually deteriorated and haemodialysis was started eventually. Three months later the patient's general condition dramatically worsened with bloody diarrhoea, bilious vomiting and progressive malnutrition. The repeated endoscopic examination confirmed severe recurrence of Whipple disease. Ceftriaxone and total parenteral nutrition was started what greatly improved patient's state. To our knowledge based on systematic review, this is the first case report on Whipple disease complicated by secondary amyl...Continue Reading

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Citations

Oct 15, 2011·Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis·Sofia RochaAntónio Cabrita
May 23, 2012·Medicina clínica·Ramon Sanmartín Sentañes, Marta Vidal Borrego
Dec 29, 2020·International Journal of Clinical Practice·Samuel DeshayesSophie Georgin-Lavialle

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Methods Mentioned

BETA
biopsy
biopsies

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