Renal and cardiac sympathetic baroreflexes in hypertensive rabbits

Clinical and Experimental Pharmacology & Physiology
G A Head, Sandra L Burke

Abstract

1. The purpose of the present study was to assess the changes to renal sympathetic nerve activity (RSNA) baroreflexes during the development of hypertension after renal clipping in conscious rabbits. 2. Rabbits were fitted with a clip on the right renal artery or underwent a sham operation under halothane anaesthesia. A recording electrode was implanted on the left renal nerve 1 week before the experiment, 3 or 6 weeks after the initial operation. During the experiment, drug-induced ramp rises and falls in mean arterial pressure (MAP) were used to produce RSNA and heart rate (HR) baroreflex curves. The RSNA for each experiment was calibrated against maximum RSNA evoked by stimulation of baroreceptor-independent trigeminal afferents. 3. Mean arterial pressure was 20 and 36% higher 3 and 6 weeks after clip implantation, respectively. Renal sympathetic nerve activity baroreflex curves were reset rightwards accordingly, but the shape of the RSNA curves was differentially affected. 4. At both hypertensive periods, MAP-HR baroreflex gain was markedly reduced due to a reduction in curvature. The HR baroreflex range was increased. The RSNA baroreflex gain was reduced at 3 weeks, which was due to a 35% lower RSNA baroreflex range, but w...Continue Reading

References

Aug 1, 1992·Clinical and Experimental Pharmacology & Physiology·G A Head, M A Adams
Jan 1, 1988·Clinical and Experimental Hypertension. Part A, Theory and Practice·E MiyajimaY Kaneko
Jan 1, 1983·Acta Physiologica Scandinavica·C MörlinB M Eriksson
Jan 1, 1995·Journal of Cardiovascular Pharmacology·G A Head
Sep 14, 1999·The American Journal of Physiology·G Hecht, A Koutsouris
Oct 7, 2000·Autonomic Neuroscience : Basic & Clinical·N Minami, G A Head

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Citations

Jul 17, 2003·Journal of Neuroscience Methods·Sandra L Burke, Geoffrey A Head
Apr 28, 2005·Clinical and Experimental Pharmacology & Physiology·Sarah-Jane GuildSimon C Malpas
Jul 2, 2009·Clinical and Experimental Pharmacology & Physiology·Roger G EvansNiwanthi W Rajapakse
Nov 23, 2012·Journal of Neuroscience Research·Anke Vermehren-SchmaedickAgnieszka Balkowiec
Mar 29, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Virginia L Brooks, Alan F Sved
May 23, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Lachlan M McDowall, Roger A L Dampney
Oct 4, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Giulianna R BorgesRubens Fazan
Jan 19, 2012·Journal of Hypertension·John-Luis MorettiGeoffrey A Head
Mar 5, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Brian E Hunt, William B Farquhar
Feb 25, 2011·Journal of Hypertension·Sandra L BurkeGeoffrey A Head
Dec 9, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Simon C Malpas
Jul 13, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Roger G EvansGeoffrey A Head
Aug 28, 2003·Clinical and Experimental Hypertension : CHE·Francesco AmentaDaniele Tomassoni
Mar 29, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·M VitelaS W Mifflin
Mar 29, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Carolyn J Barrett, Simon C Malpas
Jan 10, 2019·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Noreen F RossiMaria Maliszewska-Scislo

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