Renal and extrarenal clearance of 99mTc-MAG3: a comparison with 125I-OIH and 51Cr-EDTA in patients representing all levels of glomerular filtration rate

European Journal of Nuclear Medicine
M RehlingT Bacher

Abstract

. This investigation was undertaken in order to determine whether the clearance of technetium-99m mercaptoacetyltriglycine (99mTc-MAG3) is more closely correlated to the clearance of iodine-125 orthoiodohippurate (125I-OIH) than to the clearance of chromium-51 ethylene diamine tetra-acetate (51Cr-EDTA) and whether there is a clinically significant extrarenal clearance of 99mTc-MAG3 . Fifty-one patients with a glomerular filtration rate (GFR) of 4-132ml/min were studied. After a simultaneous single injection of the three tracers, plasma clearance was measured from blood samples 0-5h post injection (p.i.) (0-24h in patients with GFR<15ml/min). Renal plasma clearance was measured 0-5h p.i. The ratio between the renal plasma clearance of 99mTc-MAG3 and 125I-OIH was 0.57. The ratio between the renal plasma clearance of 99mTc-MAG3 and 51Cr-EDTA was 2.57. The coefficient of variation (CV) of the 99mTc-MAG3/125I-OIH ratio was significantly smaller than the CV of the 99mTc-MAG3/51Cr-EDTA ratio (13.4% versus 31.2%). The corresponding plasma clearance ratios were 0.59 (CV=14.8%) and 2.48 (CV=27.0%). Plasma clearance overestimated renal plasma clearance by 7.0ml/min (5.4%) for 99mTc-MAG3 and by 4.1ml/min (8.4%) for 51Cr-EDTA. The differenc...Continue Reading

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Citations

Apr 12, 2000·Nuclear Medicine Communications·M Rehling, L E Nielsen
Jun 14, 2001·Nuclear Medicine Communications·M RehlingJ Marqversen
Jan 13, 2006·Nuclear Medicine Communications·Tanju Yusuf ErdilTurgut Turoglu
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Apr 16, 2018·Journal of Peptide Science : an Official Publication of the European Peptide Society·Yunier Rodríguez-ÁlvarezAlicia Santos-Savio
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Dec 29, 2020·International Journal of Urology : Official Journal of the Japanese Urological Association·Nobuyuki HinataUNKNOWN Japanese Society of Endourology
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Aug 22, 2021·Clinical Physiology and Functional Imaging·Ann Mai ØstergaardJune A Ejlersen
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