Renal and Intestinal Excretion of 90 Y and 166 Ho After Transarterial Radioembolization of Liver Tumors

AJR. American Journal of Roentgenology
Robert DrescherMartin Freesmeyer

Abstract

OBJECTIVE. The aim of this study was to evaluate the amount of free radioactivity in renal and intestinal excretions during the first 48 hours after transarterial radioembolization (TARE) procedures on the liver. SUBJECTS AND METHODS. Urinary, intestinal, and biliary excretions of patients who underwent TARE with three different types of microspheres were collected during a postinterventional period of 48 hours (divided into two 24-hour intervals). Radioactivity measurements were performed. The detected amounts of activity were correlated to clinical and procedural characteristics, times of excretion, and microsphere types. RESULTS. Twenty-four patients were evaluated, 10 treated with 90Y-glass, 10 with 90Y-resin, and four with 166Ho-poly-L-lactic acid (PLLA) microspheres. Activity excretion occurred in all cases. The highest total excretion proportions of the injected activities were 0.011% for 90Y-glass, 0.119% for 90Y-resin, and 0.005% for 166Ho-PLLA microspheres. Intestinal excretion was markedly less than renal excretion (p < 0.001). Excretion after TARE with 90Y-resin was statistically significantly higher than with 90Y-glass or 166Ho-PLLA micro-spheres (p = 0.002). For each microsphere type, the excreted activity was ind...Continue Reading

References

Jan 1, 1991·International Journal of Radiation Applications and Instrumentation. Part B, Nuclear Medicine and Biology·P A SchubigerW Schilt
Mar 1, 1982·Radiology·R V MantravadiE L Felix
Oct 1, 1993·Journal of Biomedical Materials Research·E M Erbe, D E Day
Oct 19, 2006·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·R G SelwynJ A Micka
Nov 17, 2007·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Seza A Gulec, Jeffry A Siegel
May 28, 2015·Insights Into Imaging·UNKNOWN European Society of Radiology (ESR)
Sep 17, 2017·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Jip F PrinceMarnix G E H Lam
Dec 2, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Riad SalemRobert J Lewandowski
May 29, 2019·Nuclear Medicine Communications·Trifon SpyridonidisKonstantinos Katsanos

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