Abstract
The clinical importance of selection of different antihypertensive drugs for the treatment of diabetic patients is still unclear. Thus we performed a randomised, controlled study in 105 hypertensive non-insulin-dependent diabetic (NIDDM) patients with microalbuminuria over 1 year. Patients received either the angiotensin converting enzyme (ACE) inhibitor ramipril (2.5-5.0 mg/day; in addition 24% of patients also received felodipine) or the beta blocking agent atenolol (50-100 mg/day; in addition 24% of patients also received hydrochlorothiazide). Blood pressure, metabolic control, lipid levels and albumin excretion rate were studied during the follow-up. After 1 year an almost identical fall (p < 0.001) in blood pressure was observed with ramipril (170/100 vs 150/ 85 mmHg, median) and atenolol (180/100 vs 150/ 80 mmHg, median). With ramipril a reduction of total cholesterol (6.3 vs 5.9 mmol/l), of LDL cholesterol (3.8 vs 3.6 mmol/l) and HDL cholesterol (1.3 vs 1.2 mmol/l) was found, whereas triglycerides slightly increased (1.8 vs 2.0 mmol/l). With atenolol a similar reduction of total cholesterol (6.3 vs 5.9 mmol/l), LDL cholesterol (3.8 vs 3.7 mmol/l) and HDL cholesterol (1.4 vs 1.2 mmol/l) and an increase of triglycerides (1...Continue Reading
Citations
Jul 2, 2002·Lancet·Christian J Wiedermann
May 23, 1998·Diabetes Research and Clinical Practice·N EiblG Schernthaner
Aug 12, 1998·Diabetes Research and Clinical Practice·G Mertes
Dec 5, 2009·Clinical and Experimental Nephrology·UNKNOWN Japanese Society of Nephrology
Nov 26, 2015·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Xinfang XieHaiyan Wang
Mar 19, 2004·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·B KasiskeUNKNOWN National Kidney Foundation
Jan 7, 2004·Diabetic Medicine : a Journal of the British Diabetic Association·C E Mogensen, M E Cooper
Nov 8, 2013·Expert Opinion on Pharmacotherapy·Roberto FogariAngela D'Angelo
May 24, 2014·Journal of the American Society of Nephrology : JASN·James P CorsettiRobin P F Dullaart
Apr 25, 2003·Diabetologia·M D RobertsonK N Frayn
Apr 23, 2004·Drugs·Katherine F CroomCaroline M Perry
Jul 24, 2001·Blood Pressure. Supplement·H H Parving
Sep 4, 2016·Age·Stephen R SpindlerJames M Flegal
Feb 28, 2021·Kidney International·UNKNOWN Kidney Disease: Improving Global Outcomes (KDIGO) Blood Pressure Work Group