Renal and segmental artery hemodynamic response to acute, mild hypercapnia

American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Christopher L ChapmanBlair D Johnson

Abstract

Profound increases (>15 mmHg) in arterial carbon dioxide (i.e., hypercapnia) reduce renal blood flow. However, a relatively brief and mild hypercapnia can occur in patients with sleep apnea or in those receiving supplemental oxygen therapy during an acute exacerbation of chronic obstructive pulmonary disease. We tested the hypothesis that a brief, mild hypercapnic exposure increases vascular resistance in the renal and segmental arteries. Blood velocity in 14 healthy adults (26 ± 4 yr; 7 women, 7 men) was measured in the renal and segmental arteries with Doppler ultrasound while subjects breathed room air (Air) and while they breathed a 3% CO2, 21% O2, 76% N2 gas mixture for 5 min (CO2). The end-tidal partial pressure of CO2 ([Formula: see text]) was measured via capnography. Mean arterial pressure (MAP) was measured beat to beat via the Penaz method. Vascular resistance in the renal and segmental arteries was calculated as MAP divided by blood velocity. [Formula: see text] increased with CO2 (Air: 45 ± 3, CO2: 48 ± 3 mmHg, P < 0.01), but there were no changes in MAP (P = 0.77). CO2 decreased blood velocity in the renal (Air: 35.2 ± 8.1, CO2: 32.2 ± 7.3 cm/s, P < 0.01) and segmental (Air: 24.2 ± 5.1, CO2: 21.8 ± 4.2 cm/s, P < 0...Continue Reading

References

Jun 1, 1991·The Journal of Clinical Investigation·V K SomersF M Abboud
Jan 1, 1989·Upsala Journal of Medical Sciences·T GislasonG Boman
Oct 1, 1989·Journal of the Autonomic Nervous System·Y FukudaA Trzebski
Mar 1, 1988·The American Journal of Physiology·B R Walker, B L Brizzee
Sep 1, 1970·The American Journal of Physiology·J N NormanG Smith
Nov 11, 1967·The American Journal of Physiology·R M DaughertyF J Haddy
Aug 1, 1995·Journal of Applied Physiology·U LeuenbergerL Sinoway
May 1, 1993·Journal of Applied Physiology·K H WesselingJ J Schreuder
Nov 1, 1996·Cardiovascular Research·P MarracciniA L'Abbate
Aug 22, 2001·American Journal of Physiology. Heart and Circulatory Physiology·J K ShoemakerR L Hughson
Dec 26, 2001·Current Opinion in Nephrology and Hypertension·Pontus B Persson
Mar 22, 2002·The New England Journal of Medicine·Richard J JohnsonBernardo Rodriguez-Iturbe
May 17, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Afsana MomenLawrence I Sinoway
Apr 2, 2005·Experimental Physiology·Lysander W J Bogert, Johannes J van Lieshout
Feb 7, 2006·Journal of the American College of Cardiology·Ganesh ManoharanBernard De Bruyne
Nov 30, 2006·PLoS Medicine·Colin D Mathers, Dejan Loncar
Dec 15, 2007·Chest·Naoko KawataTakayuki Kuriyama
Jun 14, 2008·Journal of Hypertension·Ilja GuelenWillem Jan W Bos
May 15, 2009·Blood Purification·Gang Jee KoHeitham T Hassoun
Nov 19, 2014·International Journal of Chronic Obstructive Pulmonary Disease·Simon E Brill, Jadwiga A Wedzicha
Oct 10, 2015·International Journal of Chronic Obstructive Pulmonary Disease·M F BarakatJ K Quint
Mar 5, 2016·Journal of Nephrology·Luca ViscontiAntonio Lacquaniti
Jan 1, 2015·Nature Reviews. Disease Primers·Patrick LévyJean-Louis Pépin
Apr 13, 2017·International Urology and Nephrology·Pilar DomenechCarlos G Musso
May 17, 2017·Geriatrics & Gerontology International·Andrea CorsonelloRaffaele Antonelli-Incalzi
Dec 13, 2017·Respiratory Medicine·Timm GreulichClaus F Vogelmeier
Oct 3, 2018·International Journal of Chronic Obstructive Pulmonary Disease·Chih-Cheng LaiLikwang Chen
Jan 29, 2019·Frontiers in Physiology·Zachary J SchladerBlair D Johnson
Aug 16, 2019·Journal of Applied Physiology·Christopher L ChapmanZachary J Schlader
Feb 7, 2020·Journal of Applied Physiology·Christopher L ChapmanZachary J Schlader
Feb 23, 2020·Journal of Applied Physiology·Christopher L ChapmanZachary J Schlader

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Citations

May 7, 2020·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Gina L C Yosten
May 18, 2021·Temperature : Multidisciplinary Biomedical Journal·Christopher L ChapmanZachary Schlader

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