Renal atrial natriuretic factor receptors in hamster cardiomyopathy

Kidney International
S Mukaddam-DaherJ Gutkowska

Abstract

Hamsters with cardiomyopathy (CMO), an experimental model of congestive heart failure, display stimulated renin-angiotensin-aldosterone and enhanced sympathetic nervous activity, all factors that lead to sodium retention, volume expansion and subsequent elevation of plasma atrial natriuretic factor (ANF) by the cardiac atria. However, sodium and water retention persist in CMO, indicating hyporesponsiveness to endogenous ANF. These studies were undertaken to fully characterize renal ANF receptor subtypes in normal hamsters and to evaluate whether alterations in renal ANF receptors may contribute to renal resistance to ANF in cardiomyopathy. Transcripts of the guanylyl cyclase-A (GC-A) and guanylyl cyclase B (GC-B) receptors were detected by quantitative polymerase chain reaction (PCR) in renal cortex, and outer and inner medullas. Compared to normal controls, the cardiomyopathic hamster's GC-A mRNA was similar in cortex but significantly increased in outer and inner medulla. Levels of GC-B mRNA were not altered by the disease. On the other hand, competitive binding studies, autoradiography, and affinity cross-linking demonstrated the absence of functional GC-B receptors in the kidney glomeruli and inner medulla. Also, C-type nat...Continue Reading

References

Jan 1, 1992·Endocrinology·S Canaan-KühlR E Pratt
Oct 1, 1992·The Journal of Clinical Investigation·J P ValentinM H Humphreys
Nov 1, 1992·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·R L JamisonR Pratt
Jan 1, 1991·The Journal of Clinical Investigation·D RitterJ E Greenwald
Jul 1, 1987·The American Journal of Physiology·J B Smith, T M Lincoln
May 1, 1989·The Journal of Clinical Investigation·J GutkowskaP Sirois
Mar 15, 1989·Biochemical and Biophysical Research Communications·E R LevinS Mills
Jan 1, 1987·International Journal of Radiation Applications and Instrumentation. Part B, Nuclear Medicine and Biology·J Gutkowska
Oct 14, 1987·Biochemical and Biophysical Research Communications·Y SaitoK Obata
Jan 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·R QuirionT V Dam
Sep 17, 1984·Biochemical and Biophysical Research Communications·P HametJ Genest
Oct 1, 1995·Endocrinology·S Mukaddam-DaherE W Quillen

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Citations

May 22, 2002·Journal of Cardiovascular Pharmacology·Rouwayda El-AyoubiSuhayla Mukaddam-Daher
Mar 31, 1999·Endocrinology·D Brenner, R Gerstberger
Jun 13, 2014·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Sofia JönssonMichael Hultström

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