Renal autoimmune epitope of group A streptococci specified by M protein tetrapeptide Ile-Arg-Leu-Arg.

Proceedings of the National Academy of Sciences of the United States of America
W Kraus, E H Beachey

Abstract

The renal glomerular cross-reactivity of the amino-terminal region of type 1 streptococcal M protein was investigated. Antisera raised in rabbits against a synthetic peptide representing residues 1-26 and a peptide from which residues 20-22 had been omitted during synthesis were capable not only of opsonizing type 1 streptococci but also of reacting in immunofluorescence tests with human renal glomeruli. The cross-reactions were completely inhibited by the immunizing peptides. By using additional synthetic peptides in these inhibition studies, the glomerular cross-reactive epitope was localized to a tetrapeptide sequence Ile-Arg-Leu-Arg at positions 23-26. A number of synthetic M1 peptides containing the tetrapeptide sequence were inhibitory, whereas the M1 peptides lacking the sequence or unrelated tetrapeptides Arg-Gly-Asp-Ser or Arg-Gly-Phe-Ser were without effect. Furthermore, Ile-Arg-Leu-Arg affinity-purified antibodies reacted with renal glomeruli, and the reactivity was inhibited by the tetrapeptide as well as by type 1 M protein. These results indicate that a renal glomerular autoimmune epitope resides in a tetrapeptide Ile-Arg-Leu-Arg near the amino terminus of type 1 streptococcal M protein.

References

Aug 1, 1985·The Journal of Experimental Medicine·J B Dale, E H Beachey
May 1, 1986·The Journal of Experimental Medicine·J B Dale, E H Beachey
Nov 1, 1986·The Journal of Experimental Medicine·J B Dale, E H Beachey
Jan 25, 1985·Science·K Krisher, M W Cunningham
Jan 1, 1985·The Journal of Experimental Medicine·J B Dale, E H Beachey
Nov 1, 1969·The Journal of Experimental Medicine·J SwansonE C Gotschlich
Mar 1, 1967·European Journal of Biochemistry·P Edman, G Begg
Jul 1, 1984·The Journal of Experimental Medicine·J B RothbardG K Schoolnik
Apr 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·E H BeacheyL Chedid
Aug 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·G N PhillipsV A Fischetti

❮ Previous
Next ❯

Citations

Jul 24, 2010·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·T Matthew EisonRobert J Wyatt
Feb 1, 1989·Current Opinion in Immunology·S H Kaufmann
Mar 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·P LaingC B Pert
Feb 1, 1989·The Journal of Experimental Medicine·W KrausE H Beachey
Jul 25, 2000·Clinical Microbiology Reviews·M W Cunningham
Apr 9, 2001·Infection and Immunity·D G McLellanJ B Dale
Mar 8, 2007·Kidney International·B Rodríguez-Iturbe, S Batsford
Mar 1, 1991·Kidney International·C B Wilson
Nov 1, 1990·Zentralblatt Für Bakteriologie : International Journal of Medical Microbiology·S BirkholzW Opferkuch
Mar 2, 1991·BMJ : British Medical Journal·T Vyse
Jul 1, 1989·Clinical Microbiology Reviews·V A Fischetti
Mar 1, 1990·Infection and Immunity·J B DaleD Schifferli
Aug 1, 1989·Infection and Immunity·W KrausE H Beachey

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.