Renal blood flow and metabolism after cold ischaemia: peroperative measurements in patients with calculi

Clinical Physiology
J H Henriksen, H K Petersen

Abstract

Peroperative measurements of renal blood flow (RBF), renal O2-uptake, and renal venous lactate/pyruvate (L/P) ratio were performed before and after a period of 30-71 min of hypothermic (10-15 degrees C) renal ischaemia in nine patients, undergoing surgery for renal calculi. Before ischaemia, RBF correlated inversely to arterial-renal venous O2-difference (r = -0.74, P less than 0.05, n = 9) and directly to the preoperatively estimated unilateral glomerular filtration rate (r = 0.76, P less than 0.05, n = 8). After hypothermic ischaemia RBF decreased on the average by 42% (P less than 0.01) immediately after re-established perfusion and 36% (P less than 0.02) 30 min later. In one additional patient, who had a short warm ischaemia (8 min), the flow pattern was the same. As arterial pressure remained constant, the reduced RBF signifies an increased renal vascular resistance. Renal O2-uptake and renal venous L/P ratio were almost constant, indicating no significant anaerobic processes being involved in the flow response. None of the patients showed any signs of reactive hyperaemia. It is concluded that hypothermic renal ischaemia may be followed by an increased renal vascular resistance even when signs of anaerobic metabolism are s...Continue Reading

References

Jan 1, 1977·Scandinavian Journal of Urology and Nephrology·H K PetersenH G Iversen
Jan 1, 1977·Acta Anaesthesiologica Scandinavica·B H JensenJ Bröchner-Mortensen
Jan 1, 1975·Kidney International·A L RileyN G Levinsky
Oct 1, 1975·Scandinavian Journal of Clinical and Laboratory Investigation·M StöckelP Rödbro
Jan 1, 1974·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·S PetterssonT Scherstén
Nov 1, 1972·Scandinavian Journal of Clinical and Laboratory Investigation·J Bröchner-Mortensen
Jan 1, 1972·The Journal of Clinical Investigation·J FloresA Leaf
Nov 1, 1959·The American Journal of Physiology·M N LEVY

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Citations

May 1, 1987·Metabolism: Clinical and Experimental·J H HenriksenJ B Bülow
Nov 1, 1985·Scandinavian Journal of Clinical and Laboratory Investigation·J H HenriksenJ Giese
Aug 7, 2009·European Urology·Frank BeckerMichael Stöckle

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