Renal blood perfusion in GK rats using targeted contrast enhanced ultrasonography

Asian Pacific Journal of Tropical Medicine
Bo LiuFang Ma

Abstract

To explore application of targeted contrast enhanced ultrasonography in diagnosis of early stage vascular endothelial injury and diabetic nephropathy. Targeted SonoVue-TM microbubble was prepared by attaching anti-TM monoclonal antibody to the surface of ordinary microbubble SonoVue by biotin - avidin bridge method and ultrasonic instrument was used to evaluate the developing situation of targeted microbubble in vitro. Twenty 12-week-old male GK rats and 20 Wistar rats were enrolled in this study, and were randomly divided into targeted angiography group and ordinary angiography group. Targeted microbubbles SonoVue-TM or general microbubble SonoVue were rapidly injected to the rats via tail vein; the developing situation of the two contrast agents in rats kidneys was dynamically observed. Time-intensity curve was used to analyze rat kidney perfusion characteristics in different groups. Targeted ultrasound microbubble SonoVue-TM was successfully constructed, and it could be used to develop an external image. Targeted microbubbles SonoVue-TM enabled clear development of experimental rat kidney. Time-intensity curve shapes of rat kidney of the two groups showed as single apex with steep ascending and slowly descending branch. Comp...Continue Reading

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Citations

Sep 20, 2017·Journal of the American Society of Nephrology : JASN·Travis D HullKenneth Hoyt
Mar 21, 2017·International Journal of Biomedical Imaging·Hamid Tayebi KhosroshahiAbolhassan Shakeri Bavil
Mar 5, 2021·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Nieun SeoYong Eun Chung

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