PMID: 8614592Dec 1, 1995Paper

Renal calcification in the first year of life

Pediatric Clinics of North America
M G Karlowicz, R D Adelman

Abstract

The introduction of renal ultrasound technology has shown renal calcification to be more common in infancy than was previously believed. Understanding the role of inhibitors and promoters in crystal formation helps elucidate the pathophysiology of nephrocalcinosis. Identification of the presence or absence of hypercalcemia and hypercalciuria is an effective way to direct the diagnostic work-up of infants with nephrocalcinosis. The sonographic image of renal calcification resolves spontaneously in many infants. Whether microscopic nephrocalcinosis persists below the threshold of ultrasonographic detection is unknown. Renal calcification can be associated with persistent renal function abnormalities if hypercalciuria continues, such as in VLBW infants who receive long-term furosemide therapy after discharge from the hospital. Renal calcification may also progress to renal failure, such as in infants with primary hyperoxaluria, owing to the persistence of hyperoxaluria, a potent promoter of calcium crystal formation.

Citations

May 8, 2003·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Amitava PahariWilliam G van't Hoff
Jun 24, 2005·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Ari Auron, Uri S Alon
May 15, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Anke L L LamerisJoost G J Hoenderop
Oct 22, 2013·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Stefano GuarinoAngela La Manna
Dec 12, 2001·Journal of Pediatric Gastroenterology and Nutrition·H KalhoffF Manz
Aug 26, 2006·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Jianping HuangJohn R Burke

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