Renal cell cancer after kidney transplantation

Langenbeck's Archives of Surgery
Dennis Kleine-DöpkeHarald Schrem

Abstract

This study aims to identify modifiable risk factors for de novo renal cell carcinoma (RCC) after kidney transplantation in a matched-pair approach matching for unmodifiable factors. One thousand six hundred fifty-five adults who underwent kidney transplantation in the period 1 January 2000 to 31 December 2012 were analyzed. Patients with RCC after kidney transplantation were matched in a 1:2 ratio with those without RCC using the indication for transplantation, age at transplantation (± 10 years), recipient sex (male/female), number of received transplants, living organ donor transplantation (yes/no), and time of follow-up in days as matching criteria. The paired t test was used to compare continuous variables and the Cochran-Mantel-Haenszel test for categorical variables. Multivariable conditional logistic regression modeling was used to identify independent risk factors for RCC. In matched-pair analysis, a total number of 26 incident cases with RCC after kidney transplantation could be matched. Post-transplant RCC was significantly associated with longer durations of pre-transplant hemodialysis (p = 0.007) and post-transplant immunosuppression with cyclosporine (p = 0.029) and/or mycophenolate mofetil (p = 0.020) and with lar...Continue Reading

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Citations

May 30, 2019·Oncotarget·Anna BuxedaJulio Pascual
Feb 29, 2020·International Urology and Nephrology·Lionel VaudreuilXavier Tillou
Dec 16, 2020·Urology Case Reports·Bishoy HannaMatthew Winter
Dec 17, 2021·Current Urology Reports·Cristian Axel Hernández-GaytánAna María Autrán-Gómez

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