Renal cell carcinoma: complete response

Anti-cancer Drugs
Ovidio Fernández CalvoLuis Miguel Antón Aparicio

Abstract

A 63-year-old male, ex-smoker since 2000 underwent left radical nephrectomy in June 2004 after being diagnosed with stage II, pT3bN0M0 clear cell carcinoma. In June 2006, a control CT showed a nodule in the superior lobe, on a peripheral location, and another nodule in the base of the right lung. The patient underwent atypical resections of both nodules, confirming the presence of metastatic disease. In August 2006 the patient started treatment with sunitinib (50 mg/day for 4 weeks, with 2 weeks of rest). A total of nine cycles were administered. Periodic monitoring showed good tolerance, only presenting grade 2 erythrodisesthesia and grade 2 thrombocytopenia. CT studies performed every three cycles showed no evidence of disease recurrence. The last cycle was administered in September 2007 and PET imaging confirmed the absence of recurrence. With the patients consent, treatment was interrupted and periodic radiological and clinical examinations were performed. The patient remained asymptomatic until March 2008 when a control CT revealed an objective progression of the disease at the left lung and mediastinum level. Treatment with sunitinib was restarted at the same doses, completing a total of three cycles, achieving a complete...Continue Reading

References

Dec 7, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Robert J MotzerBrian I Rini
Jun 8, 2006·JAMA : the Journal of the American Medical Association·Robert J MotzerM Dror Michaelson
Jan 12, 2007·The New England Journal of Medicine·Robert J MotzerRobert A Figlin
Aug 7, 2007·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J MedioniS Oudard
Feb 15, 2008·Clinical Genitourinary Cancer·Daniel Y C HengRonald M Bukowski

❮ Previous
Next ❯

Citations

Nov 1, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Glenn LiuGeorge Wilding
May 28, 2013·Clinical Genitourinary Cancer·Ana M MolinaRobert J Motzer
Mar 1, 2012·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·Amy K LeblancFederica Morandi
Jan 11, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Laurence AlbigesBernard Escudier
Jun 18, 2010·Expert Review of Anticancer Therapy·Nathan LawrentschukIan D Davis

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adenocarcinoma, Clear Cell

Clear Cell Adenocarcinoma is a tumor that arises in the female genital tract and is characterized by cells that appear clear under the microscope. Discover the latest research here.