journal cover

Renal Cell Carcinoma (RCC) Tumors Display Large Expansion of Double Positive (DP) CD4+CD8+ T Cells With Expression of Exhaustion Markers

Frontiers in Immunology

Dec 12, 2018

Laurence C MenardSteven G Nadler

Abstract

Checkpoint inhibitors target the inhibitory receptors expressed by tumor-infiltrating T cells in order to reinvigorate an anti-tumor immune response. Therefore, understanding T cell composition and phenotype in human tumors is crucial. We analyzed by flow cytometry tumor-infiltrating ly...read more

Mentioned in this Paper

Immune Response
Flow Cytometry
T-Lymphocyte
Lung
RNA, Double-Stranded
Neoplasms
CD8-Positive T-Lymphocytes
Cell Growth
Programmed Cell Death Protein 1
Pharmacologic Substance
Paper Details
References
  • References
  • Citations
  • finger pointing at paper

    References currently unavailable

    We're still populating references for this paper, please check back later.
  • References
  • Citations
  • quote and clock

    No citations available

    This paper may not have been cited yet.

Similar Papers Found In These Feeds

Non-Small Cell Lung Cancer Recurrence

Immune Therapies In Cancer

Immunotherapy in cancer is used to help the immune system fight against invading cancer cells. It is used to slow the progression of the disease and prevent metastasis while enhancing the immune response. There are different types, including monoclonal antibodies and checkpoint inhibitors. Here is the latest research on immune therapies in cancer.

Follicular T Helper Cells

Follicular t helper cells are an important subset of helper t-cells which help to the formation of germinal centers and b-cells differentiation. Discover the latest research on follicular t helper cells here.

T cells: Costimulatory Receptors

T cell activation requires engagement of both the T cell receptor and a co-stimulatory molecule. Lack of a co-stimulatory signal can result in T cell anergy, deletion, or immune tolerance. Find the latest research on T cell co-stimulatory receptors here.

Cross-Priming

Cross-priming is the process whereby professional APC, mainly dendritic cells, prime t-cells by presenting antigens processed from proteins of other cells such as tumor cells or virus-infected cells. Discover the latest research on cross-priming here.

Kidney Carcinoma

Kidney or renal carcinoma is a malignant tumor that start in the kidney. Renal cell carcinoma and transitional cell carcinoma are the two most common types of kidney cancer. Several factors, both genetic and environmental, have been implicated in this cancer. Here is the latest research.

Renal Cell Carcinoma

Renal cell carcinoma, the most common type of kidney cancer, originates in the lining of the proximal convoluted tubule. Both genetic and lifestyle factors have been implicated with increased risk of developing this cancer. Here is the latest research on renal cell carcinoma.

© 2020 Meta ULC. All rights reserved

Renal Cell Carcinoma (RCC) Tumors Display Large Expansion of Double Positive (DP) CD4+CD8+ T Cells With Expression of Exhaustion Markers

Frontiers in Immunology

Dec 12, 2018

Laurence C MenardSteven G Nadler

PMID: 30534127

DOI: 10.3389/fimmu.2018.02728

Abstract

Checkpoint inhibitors target the inhibitory receptors expressed by tumor-infiltrating T cells in order to reinvigorate an anti-tumor immune response. Therefore, understanding T cell composition and phenotype in human tumors is crucial. We analyzed by flow cytometry tumor-infiltrating ly...read more

Mentioned in this Paper

Immune Response
Flow Cytometry
T-Lymphocyte
Lung
RNA, Double-Stranded
Neoplasms
CD8-Positive T-Lymphocytes
Cell Growth
Programmed Cell Death Protein 1
Pharmacologic Substance

Similar Papers Found In These Feeds

Related Papers

Paper Details
References
  • References
  • Citations
  • finger pointing at paper

    References currently unavailable

    We're still populating references for this paper, please check back later.
  • References
  • Citations
  • quote and clock

    No citations available

    This paper may not have been cited yet.
/papers/renal-cell-carcinoma-rcc-tumors-display-large/30534127