Renal cell carcinoma with vena caval involvement: a contemporary clinicopathologic analysis of 53 cases

Human Pathology
Ifeoma U NwadeiAdeboye O Osunkoya

Abstract

A clinicopathologic analysis of patients with renal cell carcinoma (RCC) and vena caval involvement diagnosed at our institution was performed. Multiple clinicopathologic parameters were examined. Fifty-three cases were identified. Mean patient age was 62 years (range, 40-82 years). The cohort comprised 36 of 53 (68%) men and 17 of 53 (32%) women. Mean primary tumor size was 10.4 cm (range, 3.1-21.0 cm). The breakdown of tumor stage was as follows: 37 of 53 (70%) were pT3b, 14 of 53 (26%) were pT3c, and 2 of 53 (4%) were pT4. Most of the tumors were clear cell RCC (45/53, 84.6%), although other variants were also represented. All cases were Fuhrman nuclear grade 3 (34/53, 64%) or 4 (19/53, 36%). Tumor necrosis was present in 41 of 53 (77%) cases. At the time of the initial tumor resection, 11 of 53 (21%) cases were staged pM1. Of the 42 patients staged as pMX at the time of primary tumor resection, 12 of 42 (29%) later developed metastasis, most commonly to the lungs. Of all 53 cases with these very advanced tumors, only 6 of 53 (11.3%) had positive surgical margins: 4 of 53 (7.5%) had positive vascular resection margins, and 2 of 53 (3.8%) had focally positive perinephric fat margins. The mean 5-year survival in our cohort was...Continue Reading

References

May 1, 1987·British Journal of Urology·R J Neves, H Zincke
Apr 20, 2007·BJU International·Stephen A BoorjianMichael L Blute
Jul 5, 2007·World Journal of Urology·Carlo TrombettaEmanuele Belgrano
Feb 22, 2008·CA: a Cancer Journal for Clinicians·Ahmedin JemalMichael J Thun
May 3, 2008·International Journal of Urology : Official Journal of the Japanese Urological Association·Masahiro TanakaYoshihiko Hirao
Nov 29, 2008·World Journal of Urology·Benjamin J CoonsPeter E Clark
Dec 20, 2011·The Journal of Thoracic and Cardiovascular Surgery·Vimal RajRaad H Mohiaddin
Oct 16, 2012·Seminars in Diagnostic Pathology·Adeboye O Osunkoya, David J Grignon
Oct 23, 2012·International Urology and Nephrology·Abhinav SidanaRonald Rodriguez
Jan 30, 2015·World Journal of Surgery·Heungman JunTae-Won Kwon
Jun 19, 2015·Canadian Urological Association Journal = Journal De L'Association Des Urologues Du Canada·Y Joseph HwangRobert Abouassaly

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